PS48

SIGMA/P0022 - ≥98% (HPLC)

Synonym: 5-(4-Chloro-phenyl)-3-phenyl-pent-2-enoic acid

CAS Number: 1180676-32-7
Empirical Formula (Hill Notation): C₁₇H₁₅ClO₂
Molecular Weight: 286.75
MDL Number: MFCD17215962
Linear Formula: C₁₇H₁₅ClO₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-P0022-5MG	5 mg	$148.00 1/EA		Add To Favorites
45-P0022-25MG	25 mg	$592.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to off-white
form	powder
InChI	1S/C17H15ClO2/c18-16-10-7-13(8-11-16)6-9-15(12-17(19)20)14-4-2-1-3-5-14/h1-5,7-8,10-12H,6,9H2,(H,19,20)/b15-12-
InChI key	LLJYFDRQFPQGNY-QINSGFPZSA-N
Quality Level	100
SMILES string	OC(=O)C=C(CCc1ccc(Cl)cc1)c2ccccc2
solubility	DMSO: >20 mg/mL
storage condition	protect from light
storage temp.	2-8°C

Biochem/physiol Actions:	PDK1 (phosphoinositide-dependent protein kinase 1) activator which binds to the HM/PIF binding pocket rather than the ATP-binding site.
Biochem/physiol Actions:	PS48 is a PDK1 (phosphoinositide-dependent protein kinase 1) activator which binds to the HM/PIF binding pocket rather than the ATP-binding site. PS48 is one of only a few truly allosteric compounds targeting a regulatory binding site on a protein kinase catalytic domain that is not adjacent to or overlapping with the ATP-binding site.
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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