Pilsicainide hydrochloride
SIGMA/P0026 - ≥98% (HPLC)
Synonym: N-
CAS Number: 88069-49-2
Empirical Formula (Hill Notation): C17H24N2O · xHCl
Molecular Weight: 272.39 (free base basis)
MDL Number: MFCD00903769
Linear Formula: C17H24N2O · xHCl
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C17H24N2O.ClH/c1-13-6- |
| InChI key | NZOSVDHCTCLGEB-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | Cl.Cc1cccc(C)c1NC(=O)CC23 |
| solubility | deionized water: >5 mg/mL |
| storage condition | desiccated |
| storage temp. | room temp |
| Application: | Pilsicainide hydrochloride has been used as a sodium channel blocker: • to study its effects on electrophysiological parameters in guinea pig pulmonary vein preparation • to study its effects on Ca2+ release and arrhythmic events in Andersen-Tawil syndrome induced pluripotent stem cells (ATS-iPSC)-derived cardiomyocytes • to study its electrophysiological effects on the guinea pig atrium |
| Biochem/physiol Actions: | Pilsicainide hydrochloride is a pure sodium channel blocker and an open channel blocker of Na+1 channels. |
| Biochem/physiol Actions: | Pilsicainide hydrochloride is a pure sodium channel blocker and an open channel blocker of Na+1 channels. Pilsicainide was defined as a pure sodium channel blocker. The compound is classified as a class Ic antiarrhythmic drug, and was originally developed in Japan. Similar to Lidocaine, Pilsicainide binds to open channels, but slowly. Pilsicainide is capable of selectively blocking the late currents in the mutant Na(+) channels that show dominant abnormal burst openings such as in δKPQ mutants. The compound is used to induce Brugada syndrome (BS) in animal models. |
| Features and Benefits: | This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Packaging: | 10, 50 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | room temp |
| UNSPSC | 12352200 |