ProTx-II
SIGMA/P0033 - ≥95% (HPLC)
Synonym: PT-II; ProToxin-II
Empirical Formula (Hill Notation): C168H250N46O41S8
Molecular Weight: 3826.59
Linear Formula: C168H250N46O41S8
Product Type: Chemical
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| assay | ≥95% (HPLC) |
| color | white |
| form | lyophilized solid |
| storage condition | under inert gas |
| storage temp. | −20°C |
| Biochem/physiol Actions: | ProTx-II is a potent, selective Nav1.7 blocker. |
| Biochem/physiol Actions: | ProTx-II is a potent, selective Nav1.7 blocker. Voltage-gated sodium channels (Nav) are responsible for transducing extracellular signals into action potentials in excitable cells. The Nav1 family consists of nine sub-types for which selective tools are highly valued. Discovery of subtype-selective tools has been challenging due to conservation of putative binding sites. Nav1.7 is expressed in sensory neurons and is critical for pain processing. ProTx-II, isolated from the tarantula Thrixopelma pruriens, is a potent blocker of Nav1 channels. Although ProTx-II blocks several members of this channel family, it has >100-fold selectivity for Nav1.7. ProTx-II is active in an in vitro model of pain processing. ProTx-II binds to a previously unknown site on the channel, conferring selectivity and increasing its value as a research tool. It blocks Nav1.7 by decreasing conductance and shifting the activation potential in the positive direction, resulting in an overall decrease in excitability. |
| Packaging: | 100 μg in glass bottle |
| Symbol |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P301 + P310 |
| Hazard Codes | T |
| Risk Statements | 25 |
| Safety Statements | 45 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | 1 |
| Purity | ≥95% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 51111800 |