Penciclovir
SIGMA/P0035
Synonym: 2-
CAS Number: 39809-25-1
Empirical Formula (Hill Notation): C10H15N5O3
Molecular Weight: 253.26
MDL Number: MFCD15142866
Linear Formula: C10H15N5O3
Product Type: Chemical
| antibiotic activity spectrum | viruses |
| form | powder |
| InChI | 1S/C10H15N5O3/c11-10-13-8 |
| InChI key | JNTOCHDNEULJHD-UHFFFAOYSA |
| mode of action | DNA synthesis | interferes |
| enzyme | inhibits | |
| Quality Level | 100  |
| SMILES string | NC1=NC(=O)c2ncn(CCC(CO)CO |
| solubility | 0.02 M potassium phosphate: soluble 2 mg/mL |
| Application: | Penciclovir is a selective antiherpesvirus agent, particularly against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) and varicella-zoster virus (VZV). |
| Biochem/physiol Actions: | Penciclovir is converted to its active form, penciclovir triphosphate, by cellular kinases. It inhibits viral DNA polymerase by competing with deoxyguanosine triphosphate. It inhibits DNA synthesis of virus-infected cells. Penciclovir has in vitro activity against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2). It does not inhibit DNA synthesis in non-infected cells. Mode of resistance is via qualitative changes in viral thymidine kinase or DNA polymerase. |
| Other Notes: | Keep container tightly closed in a dry and well-ventilated place. |
| Packaging: | 100 mg in glass bottle |
| Hazard Codes | Xi |
| Risk Statements | 36 |
| Safety Statements | 26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| UNSPSC | 51102829 |