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PP121

SIGMA/P0036 - ≥98% (HPLC)

Synonym: 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

CAS Number: 1092788-83-4
Empirical Formula (Hill Notation): C17H17N7
Molecular Weight: 319.36
MDL Number: MFCD12912434
Linear Formula: C17H17N7
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-P0036-5MG 5 mg
 $197.00
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assay ≥98% (HPLC)
color off-white
form powder
InChI 1S/C17H17N7/c18-15-13-14(11-7-10-5-6-19-16(10)20-8-11)23-24(12-3-1-2-4-12)17(13)22-9-21-15/h5-9,12H,1-4H2,(H,19,20)(H2,18,21,22)
InChI key NVRXTLZYXZNATH-UHFFFAOYSA-N
Quality Level 100 
SMILES string Nc1ncnc2n(nc(-c3cnc4[nH]ccc4c3)c12)C5CCCC5
solubility DMSO: >10 mg/mL
storage temp. 2-8°C
Biochem/physiol Actions: PP121 blocks the vascular endothelial growth factor (VEGF) receptor and its related signaling events. It also inhibits tumor cell proliferation by targeting oncogenic tyrosine kinase and phosphoinositide 3-kinases (PI3Ks).
Biochem/physiol Actions: PP121 is a dual inhibitor of tyrosine and phosphoinositide kinases.
Biochem/physiol Actions: PP121 is a dual inhibitor of tyrosine and phosphoinositide kinases. PP121 is the first inhibitor active on both Tyrosine kinases and the phosphatidylinositol-3-OH kinase (PI(3)K) family. The inhibitor is not effecting other serine-threonine protein kinases.
Features and Benefits: This compound is a featured product for Kinase Phosphatase Biology research. Click here  to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound is featured on the Phosphoinositide Kinases  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
Hazard Codes Xn
Risk Statements 22
RIDADR NONH for all modes of transport
WGK Germany WGK 1
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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