PP242 hydrate
SIGMA/P0037 - ≥98% (HPLC), powder
Synonym: 2-
CAS Number: 1173019-76-5
Empirical Formula (Hill Notation): C16H16N6O · xH2O
Molecular Weight: 308.34 (anhydrous basis)
MDL Number: MFCD12828866
Linear Formula: C16H16N6O · xH2O
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | off-white |
| form | powder |
| InChI | 1S/C16H16N6O.H2O/c1-8(2)2 |
| InChI key | FMDOLJSFPXFBIL-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | O.CC(C)n1nc(-c2cc3cc(O)cc |
| solubility | DMSO: >10 mg/mL |
| storage temp. | 2-8°C |
| Application: | PP242 hydrate has been used: • as a mammalian target of rapamycin (mTOR) inhibitor to study its effects on rat fibroblast mTOR complex 1 and 2 (mTORC1 & 2) signaling • as an mTOR inhibitor to treat mouse embryonic fibroblasts (MEF) and cumulus cells (CCs) to study its effects on reactivation of embryonic nucleoli and ribosome biogenesis • as a target of rapamycin (TOR) kinase inhibitor for the treatment of Arabidopsis to study its effects against Fusarium graminearum infection |
| Biochem/physiol Actions: | PP242 is a potent and selective mTOR inhibitor. |
| Biochem/physiol Actions: | PP242 is a potent and selective mTOR inhibitor. PP242 is a first selective inhibitor that targets ATP domain of mTOR. |
| Features and Benefits: | This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |