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PHPS1 sodium salt hydrate

SIGMA/P0039 - ≥98% (HPLC)

Synonym: 4-[2-[1,5-dihydro-3-(4-nitrophenyl)-5-oxo-1-phenyl-4H-pyrazol-4-ylidene]hydrazinyl]-benzenesulfonic acid sodium salt hydrate

CAS Number: 314291-83-3 (free acid)
Empirical Formula (Hill Notation): C21H15N5O6S · xNa+ · yH2O
Molecular Weight: 465.44 (anhydrous free acid basis)
Linear Formula: C21H15N5O6S · xNa+ · yH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-P0039-5MG 5 mg
 $233.00
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assay ≥98% (HPLC)
color red
form solid
InChI 1S/C21H15N5O6S.Na.H2O/c27-21-20(23-22-15-8-12-18(13-9-15)33(30,31)32)19(14-6-10-17(11-7-14)26(28)29)24-25(21)16-4-2-1-3-5-16;;/h1-13,22H,(H,30,31,32);;1H2/q;+1;/p-1/b23-20+;;
InChI key KLXUVMQUEDKCKG-JBKNFAMTSA-M
Quality Level 100 
SMILES string O=C1/C(C(C2=CC=C([N+]([O-])=O)C=C2)=NN1C3=CC=CC=C3)=N/NC4=CC=C(S(=O)([O-])=O)C=C4.[Na+].O
solubility DMSO: 10 mg/mL, clear (warmed)
storage condition desiccated
storage temp. 2-8°C
Application: Phenylhydrazono pyrazolone sulfonate 1 (PHPS1) sodium salt hydrate has been used as a protein-tyrosine phosphatase (shp2) inhibitor to study its effects on bisphenol A (BPA) and nonyl phenol (NP)-induced cell proliferation of MCF7 cell. It has also been used as a shp2 inhibitor to study its pro-atherosclerotic or atheroprotective effect in vivo and in vitro.
Biochem/physiol Actions: Phenylhydrazono pyrazolone sulfonate 1 (PHPS1) represses E2-induced gene transcription and rapid DNA synthesis. It also blocks mitogen-activated protein kinase (ERK1/2) activation and reduces the cigarette smoke induced-inflammatory response in mouse lungs.
Biochem/physiol Actions: Shp-2 is a Src Homology-2 (SH2) containing phosphatase that regulates growth factor signalling.
Biochem/physiol Actions: Shp-2 is a Src Homology-2 (SH2) containing phosphatase that regulates growth factor signalling. The enzyme is expressed ubiquitously in mammalian tissues and plays essential roles in development. It is also implicated in various pathological states. PHPS1 is a selective inhibitor of Shp-2 and blocks Shp-2 dependent downstream signalling.
Features and Benefits: This compound is featured on the Phosphoprotein Phosphatases (Tyrosine)  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 2
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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