PP1
SIGMA/P0040 - ≥98% (HPLC)
Synonym: 4-
CAS Number: 172889-26-8
Empirical Formula (Hill Notation): C16H19N5
Molecular Weight: 281.36
MDL Number: MFCD01076570
Linear Formula: C16H19N5
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to off-white |
| form | powder |
| InChI | 1S/C16H19N5/c1-10-5-7-11( |
| InChI key | ZVPDNRVYHLRXLX-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | Cc1ccc(cc1)-c2nn(c3ncnc(N |
| solubility | DMSO: >20 mg/mL |
| storage temp. | room temp |
| Application: | PP1 has been used as: • an inhibitor of sarcoma (Src) family kinases (SFK) like hematopoietic cell kinase (hck) and fyn • a selective Src tyrosine kinase inhibitor in hippocampal neuronal cultures to test its effect on neurite growth • a Src-kinase blocker to test its effect on brimonidine (BMD)-induced phosphorylation in extracellular signal-activated kinases(ERK1/2) |
| Biochem/physiol Actions: | PP1 is a potent and selective Src family protein tyrosine kinase inhibitor. |
| Biochem/physiol Actions: | PP1 is a pyrazolopyrimidine compound that acts as a competitive inhibitor of adenosine triphosphate (ATP) binding. It also inhibits protein tyrosine kinase (PTK6) and may be useful in the therapeutic management of PTK6 positive based breast cancer malignancy. |
| Features and Benefits: | This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Packaging: | 5, 25 mg in glass bottle |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | room temp |
| UNSPSC | 12352200 |