PP2

SIGMA/P0042 - ≥98% (HPLC)

Synonym: 4-Amino-3-(4-chlorophenyl)-1-(t-butyl)-1H-pyrazolo[3,4-d]pyrimidine; 4-Amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine; AG 1879

CAS Number: 172889-27-9
Empirical Formula (Hill Notation): C₁₅H₁₆ClN₅
Molecular Weight: 301.77
MDL Number: MFCD01568210
Linear Formula: C₁₅H₁₆ClN₅
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-P0042-5MG	5 mg	$222.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to off-white
form	powder
InChI	1S/C15H16ClN5/c1-15(2,3)21-14-11(13(17)18-8-19-14)12(20-21)9-4-6-10(16)7-5-9/h4-8H,1-3H3,(H2,17,18,19)
InChI key	PBBRWFOVCUAONR-UHFFFAOYSA-N
Quality Level	100
SMILES string	CC(C)(C)n1nc(-c2ccc(Cl)cc2)c3c(N)ncnc13
solubility	DMSO: >10 mg/mL
storage temp.	2-8°C

Application:	PP2 has been used: • to analyze the effects of Src/focal adhesion kinase (FAK) signaling on IQ domain GTPase-activating protein 1 (IQGAP1)-mediated anoikis resistance • for Src inhibition to study its effect on epidermal growth factor receptor (EGFR) and nuclear factor erythroid 2-related factor 2 (Nrf2) phosphorylation in non-small cell lung cancer (NSCLC) cells • for pharmacological inhibition of SRC in MDA-MB-231 breast cancer cells
Biochem/physiol Actions:	PP2 is a selective inhibitor of Src-family tyrosine kinases of non-receptor tyrosine kinases (nRTK). It shows >10,000-fold selectivity over Zeta-chain-associated protein kinase 70 (ZAP-70) and Janus kinase 2 (JAK2). PP2 effectively reduces cervical cancer proliferation in vitro and in vivo.
Features and Benefits:	This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging:	5 mg in glass bottle

Symbol	GHS06
Signal word	Danger
Hazard statements	H301
Precautionary statements	P301 + P310
Hazard Codes	T
Risk Statements	25
Safety Statements	45
RIDADR	UN 2811 6.1 / PGIII
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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