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PNU-120596

SIGMA/P0043 - ≥98% (HPLC)

Synonym: N-(5-Chloro-2,4-dimethoxyphenyl)-N′-(5-methyl-3-isoxazolyl)-urea; NSC 216666

CAS Number: 501925-31-1
Empirical Formula (Hill Notation): C13H14ClN3O4
Molecular Weight: 311.72
MDL Number: MFCD00095313
Linear Formula: C13H14ClN3O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-P0043-5MG 5 mg
 $146.00
1/EA		 Add To Favorites
45-P0043-25MG 25 mg
 $557.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to off-white
form solid
InChI 1S/C13H14ClN3O4/c1-7-4-12(17-21-7)16-13(18)15-9-5-8(14)10(19-2)6-11(9)20-3/h4-6H,1-3H3,(H2,15,16,17,18)
InChI key CEIIEALEIHQDBX-UHFFFAOYSA-N
Quality Level 100 
SMILES string O=C(NC1=NOC(C)=C1)NC2=CC(Cl)=C(OC)C=C2OC
solubility DMSO: >10 mg/mL
storage temp. room temp
Biochem/physiol Actions: An allosteric modulator of α7 nicotinic receptors, N-(5-chloro-2,4-dimethoxyphenyl)-N′-(5-methyl-3-isoxazolyl)-urea (PNU-120596), causes conformational changes in the extracellular ligand binding domain similar to those caused by acetylcholinePNU-120596 is a positive allosteric modulator selective for the α7 nicotinic acetylcholine receptor. PNU-120596 produces no detectable change in currents mediated by α4β2, α3β4, α9α10 nAChRs. It increases channel mean open time, but does not affect ion selectivity. It does not bind at the agonist binding site, but induces conformational changes similar to the natural effector.
Biochem/physiol Actions: PNU-120596 is a positive allosteric modulator of the α7 nicotinic acetylcholine receptor.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. room temp
UNSPSC 12352200

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