PNU-74654

SIGMA/P0052 - ≥98% (HPLC), solid

Synonym: Benzoic acid, 2-phenoxy-, 2-[(5-methyl-2-furanyl)methylene]hydrazide

CAS Number: 113906-27-7
Empirical Formula (Hill Notation): C₁₉H₁₆N₂O₃
Molecular Weight: 320.34
MDL Number: MFCD12912438
Linear Formula: C₁₉H₁₆N₂O₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-P0052-5MG	5 mg	$156.00 1/EA		Add To Favorites
45-P0052-25MG	25 mg	$614.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to off-white
form	solid
InChI	1S/C19H16N2O3/c1-14-11-12-16(23-14)13-20-21-19(22)17-9-5-6-10-18(17)24-15-7-3-2-4-8-15/h2-13H,1H3,(H,21,22)/b20-13+
InChI key	JJEDWBQZCRESJL-DEDYPNTBSA-N
Quality Level	100
SMILES string	Cc1ccc(C=NNC(=O)c2ccccc2Oc3ccccc3)o1
solubility	DMSO: >10 mg/mL
storage temp.	2-8°C

Application:	PNU-74654 has been used: • as a β-catenin signaling inhibitor to study its effects on the funnel cartilage differentiation in Sepia sp. embryos • as a Wnt signaling inhibitor to study its effects on glycogen synthase kinase 3β (GSK-3β) inhibition in prostate cancer cell lines • as a Wnt signaling inhibitor to study its effects on leptin-induced cell proliferation in breast cancer cells
Biochem/physiol Actions:	PNU-74654 inhibits the Wnt-β catenin pathway by blocking the interaction between β-catenin and TCF (T cell factor). It is also an anti-tumor agent.
Biochem/physiol Actions:	PNU-74654 inhibits the Wnt-β catenin pathway by blocking the interaction between β-catenin and TCF (T cell factor). PNU-74654 is also an anti-tumor agent. Aberrant activation of the Wnt/β-catenin pathway (canonical pathway) is implicated in driving development/progression of different tumors, such as colon cancer, through interaction between β-catenin and T cell factor (TCF), which regulates the expression of target genes in cell proliferation and differentiation. Inhibition of this pathway activity in cancer cell lines efficiently blocks their growth. PNU-74654 inhibits this pathway by blocking the interaction between β-catenin and TCF.
Packaging:	5, 25 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P264 - P270 - P301 + P312 - P501
Hazard Codes	Xn
Risk Statements	22
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352203

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