Pro-carboxypeptidase B human
SIGMA/P0059 - ≥2.0 units/mg protein
Synonym: Thrombin Activatable Fibrinolysis Inhibitor (TAFI)
MDL Number: MFCD02689174
Product Type: Chemical
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| mol wt | 60 kDa |
| Quality Level | 200  |
| shipped in | dry ice |
| specific activity | ≥2.0 units/mg protein |
| storage temp. | −70°C |
| UniProt accession no. | P15086  |
| Biochem/physiol Actions: | TAFI is supplied in its 60 kDa zymogen form. The N-terminal of TAFI contains four N-linked glycans and a plasminogen recognition sequence. Hydrolysis of the activation peptide by thrombin releases a 36-kDa active proteolytic domain homologous to tissue carboxypeptidase B. Complexation with thrombomodulin increases thrombin activation of TAFI 1250 fold. TAFI exerts it’s inhibition of fibrinolytic activity by binding to plasminogen and by cleaving C-terminal lysine residues of fibrin resulting in the reduction of plasmin and tPA binding sites on fibrin. Experiments in TAFI-deficient mice point to a regulatory role on complement C5a. |
| Other Notes: | One unit will hydrolyze 1 micromole of Hippuryl-L-Arginine per minute at pH 7.4 at 25 °C. |
| Physical form: | Solution containing 20 mM Hepes and 150 mM Sodium chloride. pH 7.4 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| activity | specific activity: ≥2.0 units/mg protein |
| Storage Temp. | −70°C |
| UNSPSC | 12352202 |