PRIMA-1
SIGMA/P0069 - ≥98% (HPLC), solid
Synonym: 2,2-
CAS Number: 5608-24-2
Empirical Formula (Hill Notation): C9H15NO3
Molecular Weight: 185.22
MDL Number: MFCD04974196
Linear Formula: C9H15NO3
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to off-white |
| form | solid |
| InChI | 1S/C9H15NO3/c11-5-9(6-12) |
| InChI key | RFBVBRVVOPAAFS-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | OCC1(CO)N2CC[C@@H](CC2)C1 |
| solubility | H2O: >10 mg/mL |
| storage temp. | 2-8°C |
| Biochem/physiol Actions: | PRIMA-1 is a selective re-activator of mutant p53 activity in tumor cells, and an inducer of apoptosis and inhibitor of growth of human tumors with mutant p53. |
| Biochem/physiol Actions: | PRIMA-1 is a selective re-activator of mutant p53 activity in tumor cells, and an inducer of apoptosis and inhibitor of growth of human tumors with mutant p53. Mutations in the tumor suppressor p53 take place in >50% tumor cells. PRIMA-1 selectively restores sequence-specific DNA binding and transactivational activity to mutant p53 proteins at μM concentrations. PRIMA-1 works as a re-activator of the apoptotic function of mutant p53 via conformational modulation of function-specific epitopes. |
| General description: | P53-dependent reactivation and induction of massive apoptosis (PRIMA-1) is a low molecular weight compound and has a role in cancer therapy. PRIMA-1 stimulates cytotoxic effects in human cancer cells. It induces eryptosis. |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |   GHS07,GHS08 |
| Signal word | Danger |
| Hazard statements | H302 - H334 |
| Precautionary statements | P301 + P312 + P330 |
| Hazard Codes | Xn |
| Risk Statements | 22-43 |
| Safety Statements | 36/37 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |