Pefloxacin mesylate dihydrate

SIGMA/P0106

Synonym: 3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-, monomethanesulfonate, dihydrate; Pefloxacine monomethanesulfonate dihydrate; Pefloxacinium methanesulfonate dihydrate

CAS Number: 149676-40-4
Empirical Formula (Hill Notation): C₁₈H₂₈FN₃O₈S
Molecular Weight: 465.49
EC Number: 274-613-9
MDL Number: MFCD01685696
Linear Formula: C₁₇H₂₀FN₃O₃ • CH₄O₃S • 2H₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-P0106-10G	10 g	$81.50 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	Gram-negative bacteria
	Gram-positive bacteria
form	powder
InChI	1S/C17H20FN3O3.CH4O3S.2H2O/c1-3-20-10-12(17(23)24)16(22)11-8-13(18)15(9-14(11)20)21-6-4-19(2)5-7-21;1-5(2,3)4;;/h8-10H,3-7H2,1-2H3,(H,23,24);1H3,(H,2,3,4);2*1H2
InChI key	LEULAXMUNMRLPW-UHFFFAOYSA-N
mode of action	DNA synthesis \| interferes
	enzyme \| inhibits
Quality Level	100
SMILES string	O.O.CS(O)(=O)=O.CCN1C=C(C(O)=O)C(=O)c2cc(F)c(cc12)N3CCN(C)CC3
solubility	H₂O: 50 mg/mL
storage temp.	2-8°C

Application:	Pefloxacin is a synthetic broad-spectrum fluoroquinolone antibiotic that is effective against most gram-negative and gram-positive bacteria. It is used to treat gonococcal urethritis and for gram-negative-bacterial infections in the gastrointestinal system and the genitourinary tract. Pefloxacin mesylate dihydrate has been used to induce achilles tendon toxicity in rodents. It′s cytotoxicity and uptake have been studied in primary cultures of rat hepatocytes.
Biochem/physiol Actions:	Pefloxacin inhibits the bacterial enzymes DNA gyrase and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase is thought to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV is thought to be the primary target in gram-positive organisms. The inhibition of the topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. Therefore, DNA replication and transcription is inhibited . Pefloxacin is an analog of norfloxacin.
Biochem/physiol Actions:	Pefloxacin is a synthetic fluoroquinolone that functions an antibacterial agent. It is an analog of norfloxacin. Mode of Action: Pefloxacin prevents bacterial DNA replication by inhibiting DNA gyrase. Antimicrobial spectrum: Pefloxacin is highly active against Staphylococcus aureus, E. coli, other enterobacteria, and Pseudomonas aeruginosa. Active against gram-positive bacteria and excellent activity against gram-negative bacteria.
General description:	Chemical structure: fluoroquinolone
Other Notes:	Keep container tightly closed in a dry and well-ventilated place.
Packaging:	10, 50 g in poly bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H319
Precautionary statements	P305 + P351 + P338
Hazard Codes	Xn
Risk Statements	22-36
Safety Statements	26
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	2-8°C
UNSPSC	51102829

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