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PRL-3 Inhibitor I

SIGMA/P0108 - ≥98% (HPLC), solid

Synonym: 5-[[5-Bromo-2-[(2-bromophenyl)methoxy]phenyl]methylene]-2-thioxo-4-thiazolidinone; Phosphatase of regenerating liver-3, Inhibitor I

CAS Number: 893449-38-2
Empirical Formula (Hill Notation): C17H11Br2NO2S2
Molecular Weight: 485.21
MDL Number: MFCD11045303
Linear Formula: C17H11Br2NO2S2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-P0108-5MG 5 mg
 $104.00
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assay ≥98% (HPLC)
color yellow
form solid
InChI 1S/C17H11Br2NO2S2/c18-12-5-6-14(22-9-10-3-1-2-4-13(10)19)11(7-12)8-15-16(21)20-17(23)24-15/h1-8H,9H2,(H,20,21,23)/b15-8+
InChI key HXNBAOLVPAWYLT-OVCLIPMQSA-N
Quality Level 100 
SMILES string Brc1ccc(OCc2ccccc2Br)c(c1)C=C3SC(=S)NC3=O
solubility DMSO: >10 mg/mL
  H2O: <2 mg/mL
storage condition protect from light
storage temp. −20°C
Application: PRL-3 Inhibitor I has been used as an inhibitor of phosphatase of regenerating liver-3 (PRL-3):
• to test its effect on classical Hodgkin lymphoma cell survival
• in the human umbilical vein endothelial cells tube formation assay
• to test its effect on the migration of neural crest cells
Biochem/physiol Actions: PRL-3 Inhibitor I is a rhodanine derivative with an IC50 value of 0.9 μM against phosphatase of regenerating liver-3 (PRL-3), a nonclassical protein tyrosine phosphatase that has recently been shown to be involved in cancer metastasis. PRL-3 Inhibitor I reduced the invasiveness of B16F10 melanoma cells in a cell based assay.
Features and Benefits: This compound is featured on the Phosphoprotein Phosphatases (Tyrosine)  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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