PQ401

SIGMA/P0113 - ≥98% (HPLC), powder

Synonym: IGF-1R Inhibitor II; N-(5-Chloro-2-methoxyphenyl)-N′-(2-methylquinolin-4-yl)urea

CAS Number: 196868-63-0
Empirical Formula (Hill Notation): C₁₈H₁₆ClN₃O₂
Molecular Weight: 341.79
MDL Number: MFCD00160558
Linear Formula: C₁₈H₁₆ClN₃O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-P0113-10MG	10 mg	$200.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white
form	powder
InChI	1S/C18H16ClN3O2/c1-11-9-15(13-5-3-4-6-14(13)20-11)21-18(23)22-16-10-12(19)7-8-17(16)24-2/h3-10H,1-2H3,(H2,20,21,22,23)
InChI key	YBLWOZUPHDKFOT-UHFFFAOYSA-N
Quality Level	100
SMILES string	COc1ccc(Cl)cc1NC(=O)Nc2cc(C)nc3ccccc23
solubility	DMSO: >10 mg/mL
	H₂O: <2 mg/mL
storage temp.	2-8°C

Application:	PQ401 has been used as: • an insulin growth factor-1 receptor (IGF-IR) inhibitor in H1299 cells to test its effect on migration suppression • a reference inhibitor in dose-response measurements studies • an IGF1R inhibitor in sirtuin 6 (SIRT6)-deficient cardiomyocytes to test its effect on hypertrophy inhibition
Biochem/physiol Actions:	PQ401 is an insulin growth factor-1 receptor (IGF-1R) inhibitor.
Biochem/physiol Actions:	PQ401, a diaryl urea compound that serves as an anti-glioma agent.
Features and Benefits:	This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits:	This compound is featured on the InsR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging:	10 mg in glass bottle

Hazard Codes	T
Risk Statements	25
Safety Statements	45
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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