PAC-1
SIGMA/P0115 - ≥98% (HPLC)
Synonym: (4-
CAS Number: 315183-21-2
Empirical Formula (Hill Notation): C23H28N4O2
Molecular Weight: 392.49
MDL Number: MFCD03302441
Linear Formula: C23H28N4O2
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white |
| form | solid |
| InChI | 1S/C23H28N4O2/c1-2-7-20-1 |
| InChI key | YQNRVGJCPCNMKT-LFVJCYFKSA |
| Quality Level | 100  |
| SMILES string | Oc1c(CC=C)cccc1C=NNC(=O |
| solubility | deionized water: ≤2 mg/mL |
| DMSO: ≥10 mg/mL | |
| storage temp. | room temp |
| Biochem/physiol Actions: | PAC-1 is a caspase 3 activator. |
| Biochem/physiol Actions: | PAC-1 is a caspase 3 activator. Caspase activation is a key strategy in cancer therapy. Caspase 3 is a key executioner caspase and direct effector of apoptosis. Hallmark of many cancers is the circumvention of signal in the activation of executioner caspases and loss of apoptotic response. EC50 for caspase 3 activation = 0.33 μM and caspase 7= 4.5 μM. The IC50 for apoptosis induction = 0.92 μM. Elevated caspase 3 level in cancerous cell lines and tissues allows PAC-1 to selectively induce apoptosis in tissues. |
| Features and Benefits: | This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| General description: | Procaspase-activating compound 1 (PAC-1) is an ortho-hydroxy N-acyl hydrazine compound. It is cytotoxic to a variety of cancer cells, such as lymphoma, leukaemia, breast carcinoma and glioblastoma. High doses of PAC-1 can promote neuroexcitation. It helps in the in vitro autoactivation of the proenzyme protease, which acts as a prototype for other protease activating compounds. PAC-1 dependant activation of procaspase-3 is associated with the chelation of zinc. |
| Packaging: | 5, 25 mg in glass bottle |
| Hazard Codes | Xn,N |
| Risk Statements | 22-36/37/38-50/53 |
| Safety Statements | 26-36/37-60-61 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | WGK 3 |
| Purity | ≥98% (HPLC) |
| Storage Temp. | room temp |
| UNSPSC | 12352200 |