Pifithrin-μ
SIGMA/P0122 - ≥97% (HPLC), solid
Synonym: 2-
CAS Number: 64984-31-2
Empirical Formula (Hill Notation): C8H7NO2S
Molecular Weight: 181.21
MDL Number: MFCD00181531
Linear Formula: C8H7NO2S
Product Type: Chemical
| assay | ≥97% (HPLC) |
| form | solid |
| InChI | 1S/C8H7NO2S/c9-12(10,11)7 |
| InChI key | ZZUZYEMRHCMVTB-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | NS(=O)(=O)C#Cc1ccccc1 |
| solubility | DMSO: soluble >10 mg/mL, clear |
| H2O: insoluble | |
| storage condition | desiccated |
| storage temp. | 2-8°C |
| Application: | Pifithrin-μ has been used: • to treat microglial cell line to analyse its neuroprotective effect on M1-like and M2-like phenotype • as heat shock protein (HSP)-70 inhibitor, to treat transfected Marc-145 cells • to inhibit heat shock cognate 70 (Hsc70) to elucidate heat shock chaperones mouse embryonic stem cells |
| Biochem/physiol Actions: | Pifithrin-μ is an inhibitor of p53 binding and anti-apoptotic, which directly inhibits p53 binding to mitochondria as well as to Bcl-xL and Bcl-2 proteins. |
| Biochem/physiol Actions: | Pifithrin-μ is an inhibitor of p53 binding and anti-apoptotic, which directly inhibits p53 binding to mitochondria as well as to Bcl-xL and Bcl-2 proteins. PFTμ rescues cells from lethal γ-irradiation-induced cell death. Because pifithrin-μ shuts down only the p53-mitochondrial pathway without affecting the transcriptional functions of p53, it is superior to pifithrin-α. |
| Biochem/physiol Actions: | Pifithrin-μ(PFT-μ) has neuroprotective capabilities against cell death in a preclinical model of hypoxia-ischemia (HI)-induced neonatal encephalopathy. It inhibits nuclear factor-ΙB (NF-ΙB) pathway by inhibiting the interaction of molecular chaperone heat shock protein (HSP)-70 with its substrates. |
| Packaging: | 5, 10 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264 - P270 - P301 + P312 - P501 |
| Hazard Codes | Xn |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥97% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |