Anti-Potassium Channel Kv4.3 antibody produced in rabbit
SIGMA/P0358 - affinity isolated antibody, lyophilized powder
Synonym: Anti-BRGDA9; Anti-KCND3L; Anti-KCND3S; Anti-KSHIVB; Anti-KV4.3; Anti-SCA19; Anti-SCA22
MDL Number: MFCD02097221
Product Type: Chemical
Immunohistochemistry Anti-Kv4.3: Cat. No. P0358: Immunohistochemical staining of perfusion-fixed frozen Rat brain sections using Anti-Kv4.3 antibody, (1:400), followed by Donkey Anti-Rabbit-Cy3 antibody (red). Staining appears in neurons of the CA1 hippocampal region (arrow). Nuclei are stained with DAPI (blue).
Immunoblotting Anti-KV4.3: Cat. No. P0358: Western blot analysis of Rat brain membranes. Lanes 1. Anti-KV4.3 antibody, (1:200). 2. Anti-KV4.3 antibody, preincubated with the control peptide antigen.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | lyophilized powder |
| Quality Level | 100  |
| species reactivity | rat, human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable |
| western blot (chemiluminescent): 1:200 | |
| UniProt accession no. | Q9UK17  |
| Application: | Anti-Potassium Channel Kv4.3 antibody produced in rabbit has been used in immunohistochemistry. |
| Biochem/physiol Actions: | Potassium channels contribute to maintaining cell volume, neuronal excitability, and the secretion of transmitters, salt, and hormones. Potassium voltage-gated channel subfamily D member (Kv4.3) is involved in membrane repolarization in excitable cells. Kv4.3 may participate in the development of the cerebellum. It is capable of forming homo- or hetero-tetramers with the Shal subfamily channel members. KCND3 gene mutations result in Brugada syndrome and spinocerebellar ataxia type 22. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Potassium voltage-gated channel subfamily D member 3 (KCND3) gene codes for Kv4.3, an α-subunit of the Ito channel. It has seven exons and is mapped to the human chromosome 1p13.2. Kv4.3 is expressed in the brain and the heart. Anti-potassium channel Kv4.3 recognizes Kv4.3 protein in the rat by immunoblotting. |
| Immunogen: | synthetic peptide corresponding to amino acids 451-468 of rat or human potassium channel Kv4.3 (with additional N-terminal tyrosine and methionine replaced with norleucine). |
| Physical form: | Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.025% sodium azide. |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H312 + H332 - H412 |
| Precautionary statements | P273 - P280 - P302 + P352 + P312 - P304 + P340 + P312 |
| Hazard Codes | T |
| Risk Statements | 24/25-52/53 |
| Safety Statements | 36/37-45-61 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |