Anti-Potassium Channel SK2 antibody produced in rabbit
SIGMA/P0483 - affinity isolated antibody, lyophilized powder
Synonym: Apamin-Sensitive Conductance Ca2+-Dependent K+ Channel, KCa2, Kcnn2, SKCa2
MDL Number: MFCD02097223
Product Type: Chemical
Immunohistochemistry Anti-KCa2.2 (SK2): Cat. No. P0483: Immunohistochemical staining of KCa2.2 channels using Anti-KCa2.2 (SK2) antibody in Rat cerebral cortex. Picture showing the the third layer. Note that both neural (black arrows) and glial cells (green arrows) show intense staining. Reaction product is red and counterstain is H and E.
Immunoblotting Anti-KCa2.2 (SK2): Cat. No. P0483: Western blot analysis of Rat brain membranes. Lanes 1. Anti-KCa2.2 (SK2) antibody, (1:200). 2. Anti-KCa2.2 (SK2) antibody, preincubated with the control peptide antigen.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | lyophilized powder |
| Quality Level | 100  |
| species reactivity | human, rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot (chemiluminescent): 1:200 using rat brain membranes |
| UniProt accession no. | Q9H2S1  |
| Application: | Anti-Potassium Channel SK2 (Apamin-Sensitive Conductance Ca2+-Dependent K+ Channel, KCa2, Kcnn2, SKCa2) antibody produced in rabbit has been used for immunohistochemistry and immunofluorescence. |
| Biochem/physiol Actions: | Potassium calcium-activated channel subfamily N member 2 (KCNN2) or SK2 has a role in the modulation of intrinsic excitability of neurons and Purkinje cells. It also has a role in synaptic transmission and plasticity. SK2 promotes hippocampus-dependent learning and memory in the mammalian brain. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Potassium calcium-activated channel subfamily N member 2 (KCNN2) or SK2 is expressed in rat Purkinje cells. The gene encoding this protein is localized on rat chromosome 18q11. |
| Immunogen: | synthetic peptide corresponding to amino acids 542-559 of rat potassium channel SK2. |
| Physical form: | Lyophilized at 0.3-1.4 mg/mL from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.025% - 0.050% sodium azide. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |