Pentamidine isethionate salt

SIGMA/P0547 - powder

Synonym: 1,5-Bis(p-amidinophenoxy)pentane bis(2-hydroxyethanesulfonate salt); 4,4′-(Pentamethylenedioxy)dibenzamidine bis(2-hydroxyethanesulfonate)

CAS Number: 140-64-7
Empirical Formula (Hill Notation): C₂₃H₃₆N₄O₁₀S₂
Molecular Weight: 592.68
EC Number: 205-424-1
MDL Number: MFCD00079213
Linear Formula: CH₂[CH₂CH₂OC₆H₄C(=NH)NH₂]₂·2HOCH₂CH₂SO₃H
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-P0547-25MG	25 mg	$50.60 1/EA	Add To Favorites
45-P0547-100MG	100 mg	$50.50 1/EA	Add To Favorites
45-P0547-250MG	250 mg	$94.80 1/EA	Add To Favorites
45-P0547-1G	1 g	$185.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: P0547-100MG

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	fungi
form	powder
InChI	1S/C19H24N4O2.2C2H6O4S/c20-18(21)14-4-8-16(9-5-14)24-12-2-1-3-13-25-17-10-6-15(7-11-17)19(22)23;23-1-2-7(4,5)6/h4-11H,1-3,12-13H2,(H3,20,21)(H3,22,23);23H,1-2H2,(H,4,5,6)
InChI key	YBVNFKZSMZGRAD-UHFFFAOYSA-N
mode of action	enzyme \| inhibits
mp	188-194 °C (lit.)
originator	Celgene
Quality Level	100
SMILES string	OCCS(O)(=O)=O.OCCS(O)(=O)=O.NC(=N)c1ccc(OCCCCCOc2ccc(cc2)C(N)=N)cc1
storage temp.	−20°C

Application:	Antimicrobial against Pneumocystis carinii.
Application:	Pentamidine isethionate salt has been used: • as a positive control for anti-leishmanial, anti-plasmodial and cytotoxic assays • as a prototypical compound to analyse the inhibitor effect on human ether-a-go-go-related gene (HERG) K⁺ channel trafficking • as an anti-leishmanial agent in promastigotes
Biochem/physiol Actions:	Neuroprotective; inhibits constitutive nitric oxide synthase in the brain; NMDA glutamate receptor antagonist.
Biochem/physiol Actions:	Pentamidine isethionate is used as a second line drug for leishmaniasis.
Features and Benefits:	This compound was developed by Celgene . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging:	1 g in glass bottle
Packaging:	100, 250 mg in glass bottle
Packaging:	25 mg in poly bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H315 - H317 - H319 - H335
Precautionary statements	P280 - P302 + P352 - P305 + P351 + P338
Hazard Codes	Xi
Risk Statements	36/37/38-43
Safety Statements	26-36/37
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3

mp	188-194 °C (lit.)
Storage Temp.	−20°C
UNSPSC	12352200

To Order From a Quote