Parthenolide
SIGMA/P0667 - ≥98% (HPLC)
CAS Number: 20554-84-1
Empirical Formula (Hill Notation): C15H20O3
Molecular Weight: 248.32
MDL Number: MFCD00134592
Linear Formula: C15H20O3
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: P0667-25MG
| assay | ≥98% (HPLC) |
| form | powder |
| InChI | 1S/C15H20O3/c1-9-5-4-8-15 |
| InChI key | KTEXNACQROZXEV-ZRPLFPEYSA |
| mp | 115-116 °C (lit.) |
| Quality Level | 100  |
| SMILES string | C/C(CC[C@]12[H])=C/CC[C@] |
| storage temp. | 2-8°C |
| Application: | Parthenolide has been used: • in the crystallization with vasohibin 1 (VASH1) to study tubulin detyrosination inhibition • as an inhibitor of nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) and signal transduction and activation of transcription (STAT) inhibitor to study its effects on the cytoadhesion of CD36-binding Plasmodium falciparum-infected erythrocytes (IECD36) • as a lipophilic agent to study its effects on the production of interleukin?13 and interferon?γ by peripheral blood-derived CD8+ T cells |
| Biochem/physiol Actions: | Anti-inflammatory agent that inhibits NF-κB activation. |
| Biochem/physiol Actions: | Parthenolide is a sesquiterpene lactone present abundantly in the leaves and flowers of Tanacetum parthenium. It exhibits anti-cancer properties for the treatment of invasive cancers. Parthenolide exhibits therapeutic effects against inflammation and migraine. It plays a role in signal transduction and activation of transcription (STAT)-inhibition-mediate |
| Other Notes: | Sesquiterpene lactone found in feverfew (Tanacetum parthenium) and other plants. |
| Packaging: | 25 mg in glass bottle |
| Packaging: | 5 mg in glass insert |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H317 |
| Precautionary statements | P280 - P302 + P352 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| mp | 115-116 °C (lit.) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |