(±)-Propranolol hydrochloride

SIGMA/P0884 - ≥99% (TLC), powder

Synonym: (±)-1-Isopropylamino-3-(1-naphthyloxy)-2-propanol hydrochloride; DL-Propranolol hydrochloride

CAS Number: 318-98-9
Empirical Formula (Hill Notation): C₁₆H₂₁NO₂ · HCl
Molecular Weight: 295.80
EC Number: 206-268-7
MDL Number: MFCD00012558
Linear Formula: C₁₆H₂₁NO₂ · HCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-P0884-1G	1 g	$51.90 1/EA	Add To Favorites
45-P0884-5G	5 g	$182.00 1/EA	Add To Favorites
45-P0884-25G	25 g	$724.00 1/EA	Add To Favorites
45-P0884-100G	100 g	$1780.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: P0884-100G

Properties
Descriptions
Safety Info.
Basic Data

assay	≥99% (TLC)
color	white
form	powder
InChI	1S/C16H21NO2.ClH/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16;/h3-9,12,14,17-18H,10-11H2,1-2H3;1H
InChI key	ZMRUPTIKESYGQW-UHFFFAOYSA-N
originator	AstraZeneca
Quality Level	200
SMILES string	Cl.CC(C)NCC(O)COc1cccc2ccccc12
solubility	45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 8.0 mg/mL
	DMSO: <14.5 mg/mL
	ethanol: 10 mg/mL
	H₂O: 50 mg/mL
storage temp.	2-8°C

Application:	(±)-Propranolol hydrochloride has been used: • to determine whether autonomic nervous system mediated the promotive effect on skin microcirculation in rat • as a non-selective β- receptor blocker to reduce the arrhythmogenic events • to study its effect on oxygen-induced retinopathy in mice
Biochem/physiol Actions:	Propranolol hydrochloride is a β-adrenoceptor antagonist. Its action at β2 receptor results in bronchoconstriction. Due to its lipophilic nature, propranolol can penetrate to the central nervous system and has a negative effect. It serves as a 5-HT₁/5-HT₂ serotonin receptor antagonist. Propranolol hydrochloride is useful as an antihypertensive drug, cardiac depressant and also in the treatment of angina pectoris. It decreases the effect of stress and exercise on heart by reducing the rate of contraction and conduction of impulse. It is known to competitively block the action of catecholamines.
Disclaimer:	Shelf-life of the solid is at least four years if stored protected from the uptake of moisture.
Features and Benefits:	This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits:	This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits:	This compound was developed by AstraZeneca . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
General description:	dissolve with heat. Aqueous solutions are most stable at pH 3.0 and decompose rapidly at basic pH. Decomposition is accompanied by discoloration of the solution.
General description:	Propranolol hydrochloride is easily soluble in ethanol and water.
Packaging:	1, 5, 25, 100 g in poly bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P264 - P270 - P301 + P312 + P330 - P501
Hazard Codes	Xn
Risk Statements	22
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥99% (TLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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