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Palmitoyl-L-carnitine chloride

SIGMA/P1645 - ≥98% (TLC), powder

Synonym: O-Palmitoyl-L-carnitine chloride

CAS Number: 18877-64-0
Empirical Formula (Hill Notation): C23H46ClNO4
Molecular Weight: 436.07
EC Number: 242-642-6
MDL Number: MFCD00070346
Linear Formula: C23H46NO4 · Cl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-P1645-5MG 5 mg
 $0.00
1/EA
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45-P1645-10MG 10 mg
 $0.00
1/EA
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45-P1645-25MG 25 mg
 $559.00
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assay ≥98% (TLC)
color white
form powder
InChI 1S/C23H45NO4.ClH/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4;/h21H,5-20H2,1-4H3;1H/t21-;/m1./s1
InChI key GAMKNLFIHBMGQT-ZMBIFBSDSA-N
lipid type saturated FAs
Quality Level 200 
SMILES string [Cl-].CCCCCCCCCCCCCCCC(=O)O[C@H](CC(O)=O)C[N+](C)(C)C
solubility H2O: 25 mg/mL (with heat or sonication)
storage temp. −20°C
Application: Palmitoyl-L-carnitine chloride has been used as acylcarnitine in treating cardiomyocytes for the induction of reactive oxygen species (ROS).
Biochem/physiol Actions: Long-chain acylcarnitine and well-known intermediate in mitochondrial fatty acid oxidation. Modifies myocardial levels of high-energy phosphates and free fatty acids in the heart. Increases erythroid colony formation in culture. Reduces surface negative charge of erythrocytes and myocytes. Reported to affect currents and inhibit endothelium-dependent relaxation induced by acetylcholine and substance P in a dose-dependent manner by suppressing the intracellular calcium signal transduction in endothelial cells. Inhibits the Na/K pump current but has no effect on the intracellular calcium current in guinea pig ventricular cells. However, like oubain, it reversibly depolarizes the resting membrane, decreases action potential duration, and increases the amplitude of myocyte contractions.
Packaging: 10, 25 mg in poly bottle
Packaging: 5 mg in glass bottle
Purity ≥98% (TLC)
Storage Temp. −20°C
UNSPSC 12352211

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