Picrotoxin

SIGMA/P1675 - powder

Synonym: Cocculin

CAS Number: 124-87-8
Empirical Formula (Hill Notation): C₃₀H₃₄O₁₃
Molecular Weight: 602.58
EC Number: 204-716-6
MDL Number: MFCD00074824
Linear Formula: C₃₀H₃₄O₁₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-P1675-1G	1 g	$64.70 1/EA	Add To Favorites
45-P1675-5G	5 g	$269.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

color	white
form	powder
InChI	1S/C15H18O7.C15H16O6/c1-12(2,18)6-7-10(16)20-8(6)9-13(3)14(7,19)4-5-15(13,22-5)11(17)21-9;1-5(2)7-8-11(16)19-9(7)10-13(3)14(8,18)4-6-15(13,21-6)12(17)20-10/h5-9,18-19H,4H2,1-3H3;6-10,18H,1,4H2,2-3H3/t5-,6+,7+,8+,9-,13-,14-,15+;6-,7+,8+,9+,10-,13-,14-,15+/m11/s1
InChI key	VJKUPQSHOVKBCO-NGKRNLQBSA-N
mp	203 °C (lit.)
Quality Level	200
SMILES string	[H][C@@]12C[C@@]3(O)[C@@]4([H])[C@H](C(C)=C)[C@]([H])(OC4=O)[C@@]5([H])OC(=O)[C@]1(O2)[C@@]35C.[H][C@@]67C[C@@]8(O)[C@@]9([H])[C@@H]([C@]([H])(OC9=O)[C@@]%10([H])OC(=O)[C@]6(O7)[C@@]8%10C)C(C)(C)O

Application:	Picrotoxin has been used: • as non-competitive antagonist for the γ-aminobutyric acid (GABA_A) for studying synchronized burst (SB) dynamics • as a component of extracellular saline for blocking glutamate and acetylcholine receptors in neurons • as a component of artificial cerebrospinal fluid (ACSF) for voltage-clamp recordings studies in dissociated cortical neurons
Biochem/physiol Actions:	GABA_A receptor antagonist; binds to the GABA receptor-linked Cl⁻ channel.
Biochem/physiol Actions:	Picrotoxin is a competitive inhibitor of glycine receptors (GlyRs). It is a non-competitive antagonist, which binds to ligand bounded γ-aminobutyric acid (GABAA) receptor.
Features and Benefits:	This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits:	This compound is featured on the GABAA Receptors and GABAC Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
General description:	Picrotoxin is isolated from moonseed family, Menispermaceae. It is a stimulant and may cause convulsions. It is an allosteric modulator of γ-aminobutyric acid (GABA_A) receptor.
Other Notes:	2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research
Other Notes:	Molecular complex (1:1) of picrotin and picrotoxinin.
Packaging:	1, 5 g in glass bottle

Symbol	GHS06
Signal word	Danger
Hazard statements	H300
Precautionary statements	P264 - P270 - P301 + P310 + P330 - P405 - P501
Hazard Codes	T+
Risk Statements	28
Safety Statements	28-36/37/39-45
RIDADR	UN 3462 6.1 / PGII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

mp	203 °C (lit.)
UNSPSC	12352200

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