Pentoxifylline

SIGMA/P1784 - solid

Synonym: 3,7-Dimethyl-1-(5-oxohexyl)xanthine; Trental

CAS Number: 6493-05-6
Empirical Formula (Hill Notation): C₁₃H₁₈N₄O₃
Molecular Weight: 278.31
EC Number: 229-374-5
MDL Number: MFCD00063379
Linear Formula: C₁₃H₁₈N₄O₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-P1784-10G	10 g	$70.30 1/EA	Add To Favorites
45-P1784-100G	100 g	$439.00 1/EA	Add To Favorites
45-P1784-250G	250 g	$1020.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

color	white
form	solid
InChI	1S/C13H20N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8,10-11H,4-7H2,1-3H3
InChI key	MQGNNJQTNFHNHK-UHFFFAOYSA-N
originator	Sanofi Aventis
Quality Level	100
SMILES string	CN1C=NC2C1C(=O)N(CCCCC(C)=O)C(=O)N2C
solubility	H₂O: ≥43 mg/mL, colorless to almost colorless

Application:	Pentoxifylline has been used: • used in the combinatorial treatment with itraconazole for paracoccidioidomycosis (PCM) • to treat harvested sperms to check the effect of ′pentoxifylline exposed sperms′ in the contribution of embryonic growth • to intrathecally inject female and male mice to investigate whether astrocytes and microglia could be causally involved in the maintenance of pain-like behaviour
Biochem/physiol Actions:	Pentoxifylline (PTX) is considered as a nonspecific phosphodiesterase inhibitor. It possesses rheologic properties. Pentoxifylline is used to treat peripheral vascular disease. It has the ability to block the phosphorylation of I kappa B-alpha (IĸBα) in serines 32 and 36.
Biochem/physiol Actions:	Phosphodiesterase inhibitor; inhibits synthesis of tumor necrosis factor α (TNF-α).
Features and Benefits:	This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits:	This compound is featured on the Histamine Synthesis and Metabolism and Phosphodiesterases pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits:	This compound was developed by Sanofi Aventis . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .

Symbol	GHS07
Signal word	Warning
Hazard statements	H302 - H362
Precautionary statements	P201 - P202 - P260 - P263 - P301 + P312 - P308 + P313
Hazard Codes	Xn
Risk Statements	22
Safety Statements	36
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3

UNSPSC

41106305

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