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PD 123,319 di(trifluoroacetate) salt hydrate

SIGMA/P186 - powder, ≥98% (HPLC)

Synonym: S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid di(trifluoroacetate) salt hydrate

CAS Number: 136676-91-0
Empirical Formula (Hill Notation): C31H32N4O3 · 2C2HF3O2 · xH2O
Molecular Weight: 736.66 (anhydrous basis)
MDL Number: MFCD11046022
Linear Formula: C31H32N4O3 · 2C2HF3O2 · xH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-P186-10MG 10 mg
 $453.00
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assay ≥98% (HPLC)
form powder
InChI 1S/C31H32N4O3.2C2HF3O2.H2O/c1-21-16-22(14-15-26(21)33(2)3)18-34-20-32-25-19-35(28(31(37)38)17-27(25)34)30(36)29(23-10-6-4-7-11-23)24-12-8-5-9-13-24;2*3-2(4,5)1(6)7;/h4-16,20,28-29H,17-19H2,1-3H3,(H,37,38);2*(H,6,7);1H2/t28-;;;/m0.../s1
InChI key PTSUEYBWHKDYBS-FPCIESGBSA-N
SMILES string O.OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CN(C)c1ccc(Cn2cnc3CN([C@@H](Cc23)C(O)=O)C(=O)C(c4ccccc4)c5ccccc5)cc1C
solubility H2O: 10 mg/mL, clear
storage condition desiccated
storage temp. 2-8°C
Application: PD123,319 di (trifluoroacetate) salt hydrate has been used in following experimental studies:
• To determine the effect of Angiotensin II (Ang II) on alveolar fluid clearance (AFC).
• To study the effect of PD123319 on AngII-induced abdominal aortic aneurysms (AAAs).
• To study its effect on Ang II-induced LRP1 overexpression and function in vascular smooth muscle cells (VSMCs) culture.
Biochem/physiol Actions: PD123,319 di (trifluoroacetate) salt hydrate is a widely used angiotensin II subtype-2 receptor (AT2R) antagonist to study the role of AT2 receptor in vitro and in vivo. It increases the AngII-induced abdominal aortic aneurysms (AAAs) without interacting with AT2 receptor.
Disclaimer: Hygroscopic
Packaging: 10 mg in poly bottle
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352202

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