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Phenamil methanesulfonate salt

SIGMA/P203 - solid

Synonym: 3,5-Diamino-6-chloro-N-[imino(phenylamino)methyl]pyrazinecarboxamide methanesulfonate salt

CAS Number: 1161-94-0
Empirical Formula (Hill Notation): C12H12ClN7O · CH4O3S
Molecular Weight: 401.83
MDL Number: MFCD00274070
Linear Formula: C12H12ClN7O · CH3SO3H
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-P203-5MG 5 mg
 $144.00
1/EA		 Add To Favorites
45-P203-25MG 25 mg
 $489.00
1/EA		 Add To Favorites

 

color yellow
form solid
InChI 1S/C12H12ClN7O.CH4O3S/c13-8-10(15)19-9(14)7(18-8)11(21)20-12(16)17-6-4-2-1-3-5-6;1-5(2,3)4/h1-5H,(H4,14,15,19)(H3,16,17,20,21);1H3,(H,2,3,4)
InChI key MHPIZTURFVSLTJ-UHFFFAOYSA-N
Quality Level 100 
SMILES string CS(O)(=O)=O.Nc1nc(N)c(nc1Cl)C(=O)NC(=N)Nc2ccccc2
solubility 0.1 M HCl: insoluble
  45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 2.5 mg/mL
  DMSO: ≥5 mg/mL (with warming)
  H2O: insoluble
storage temp. 2-8°C
Application: Phenamil methanesulfonate salt has been used:
• to stimulate adipocyte differentiation in 3T3 cells
• to test its effect on lateral flagella expression in Vibrio shilonii
• in nanoparticle preparation to test its effect on osteo/odontoblastic differentiation
Biochem/physiol Actions: Phenamil is an inducer of peroxisome proliferator-activated receptor γ (PPARγ) and inhibits diamine oxidase. By favoring tribbles homolog 3 (Trb3) expression, phenamil holds therapeutic potential to treat pulmonary artery hypertension (PAH) and idiopathic PAH. It is also a bone morphogenetic protein (BMP) activator, which favors osteogenesis and odontogenesis of stem cells.
General description: Phenamil, a derivative of amiloride is an inhibitor of sodium channels including acid sensing ion channel (ASIC) and epithelial sodium channels (ENaC).
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Storage Temp. 2-8°C
UNSPSC 12352200

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