Pirfenidone
SIGMA/P2116 - ≥97% (HPLC)
Synonym: 5-
CAS Number: 53179-13-8
Empirical Formula (Hill Notation): C12H11NO
Molecular Weight: 185.22
MDL Number: MFCD00866047
Linear Formula: C12H11NO
Product Type: Chemical
| assay | ≥97% (HPLC) |
| form | powder |
| InChI | 1S/C12H11NO/c1-10-7-8-12( |
| InChI key | ISWRGOKTTBVCFA-UHFFFAOYSA |
| originator | Shionogi |
| Quality Level | 100  |
| SMILES string | O=C(C=CC(C)=C1)N1C2=CC=CC |
| solubility | DMSO: >20 mg/mL |
| H2O: >10 mg/mL at 60 °C (warming for 30 minutes) |
| Application: | Pirfenidone has been used: • as a post-operative eye drop in rabbits to analyse its antifibrotic effect to improve glaucoma filtration surgery • as an anti-scarring agent to examine whether it affects the foreign body reaction after glaucoma drainage device (GDD) implantation in a rabbit • to test its antifibrotic potential in primary cultures of human orbital fibroblasts (hOFs) • as tumor necrosis factor (TNFα) inhibitor to study its effect in hypoxia |
| Biochem/physiol Actions: | Inhibits collagen production and fibroblast proliferation. |
| Biochem/physiol Actions: | Pirfenidone inhibits collagen production and fibroblast proliferation. It has shown antifibrotic and anti-inflammatory properties in variety of animal models of pulmonary fibrosis, and in clinical trials. |
| Biochem/physiol Actions: | Pirfenidone is used to treat idiopathic pulmonary fibrosis (IPF). It helps to decrease the weakening of lung function decline and ameliorate progression-free survival. Pirfenidone can repress the multiplication and contraction of collagen of human tenon′s fibroblasts. |
| Features and Benefits: | This compound was developed by Shionogi . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here . |
| General description: | Pirfenidone (5-methyl-1-p |
| Packaging: | 10, 50 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264 - P270 - P301 + P312 - P501 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥97% (HPLC) |
| UNSPSC | 12352200 |