PD 98,059
SIGMA/P215 - solid
Synonym: 2-
CAS Number: 167869-21-8
Empirical Formula (Hill Notation): C16H13NO3
Molecular Weight: 267.28
MDL Number: MFCD00671789
Linear Formula: C16H13NO3
Product Type: Chemical
| color | yellow |
| form | solid |
| InChI | 1S/C16H13NO3/c1-19-14-8-4 |
| InChI key | QFWCYNPOPKQOKV-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | COc1cccc(c1N)C2=CC(=O)c3c |
| solubility | DMSO: 10 mg/mL, clear |
| storage temp. | −20°C |
| Application: | PD 98,059 has been used: • in growth medium as a mitogen-activated protein (MAP) kinase inhibitor, in order to study the secondary messengers involved in the effect of D1-like receptors • in calcium-free RPMI (Roswell park memorial institute)-1640 medium to study its effect on inflammation, proliferation and differentiation in human epidermal keratinocyte cell line in conjunction of cystic fibrosis transmembrane conductance regulator (CFTR) knockdown • in culture medium for cell migration assay |
| Biochem/physiol Actions: | PD 98,059 is a flavonoid and specific inhibitor of mitogen-activated protein kinase kinase (MAPKK). In mice, PD 98,059 helps to block zymosan stimulated organ dysfunction syndrome and non-septic shock. It is known to inhibit in vitro hypertrophy. PD 98,059 also induces cartilage formation in mesenchymal stromal cells. |
| Features and Benefits: | This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Legal Information: | Sold with permission of Warner Lambert Company. |
| Packaging: | 1, 5 mg in glass bottle |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |