Pamidronate disodium salt hydrate

SIGMA/P2371 - ≥95% (NMR), solid

Synonym: 3-Amino-1-hydroxy-1-phosphonopropanephosphonic acid disodium salt hydrate

CAS Number: 57248-88-1 (anhydrous)
Empirical Formula (Hill Notation): C₃H₉NO₇P₂Na₂ · xH₂O
Molecular Weight: 279.03 (anhydrous basis)
EC Number: 260-647-1
MDL Number: MFCD11045314
Linear Formula: C₃H₉NO₇P₂Na₂ · xH₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-P2371-10MG	10 mg	$147.00 1/EA	Add To Favorites
45-P2371-100MG	100 mg	$679.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥95% (NMR)
color	white
form	solid
InChI	1S/C3H11NO7P2.2Na.H2O/c4-2-1-3(5,12(6,7)8)13(9,10)11;;;/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11);;;1H2/q;2*+1;/p-2
InChI key	TVQNUQCYOOJTMK-UHFFFAOYSA-L
mp	300 °C
originator	Novartis
Quality Level	100
SMILES string	O.[Na+].[Na+].NCCC(O)(P(O)([O-])=O)P(O)([O-])=O
solubility	H₂O: 28 mg/mL
storage temp.	2-8°C

Biochem/physiol Actions:	Bone resorption inhibitor; inhibitor of farnesyl diphosphate synthase (IC₅₀= 200 nM).
Biochem/physiol Actions:	Pamidronate disodium has the ability to block Wnt and β-catenin signaling, which modulates the osteogenic differentiation in bone marrow mesenchymal stem cells (BMMSCs). It can also reduce bilirubin-impaired apoptosis and helps to develop dentinogenic dysfunction of stem cells from human deciduous teeth.
Features and Benefits:	This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits:	This compound was developed by Novartis . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging:	10, 100 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H302
Hazard Codes	Xn
Risk Statements	22
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥95% (NMR)
mp	300 °C
Storage Temp.	2-8°C
UNSPSC	12352200

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