L-α-Phosphatidylcholine
SIGMA/P2772 - egg yolk, Type XI-E, 100 mg/mL in chloroform, ≥99%, solution
Synonym: 1,2-Diacyl-sn-
CAS Number: 8002-43-5
Product Type: Chemical
| assay | ≥99% |
| biological source | egg yolk |
| concentration | 100 mg/mL in chloroform |
| form | solution |
| functional group | phospholipid |
| InChI | 1S/C42H80NO8P/c1-6-8-10-1 |
| InChI key | JLPULHDHAOZNQI-ZTIMHPMXSA |
| lipid type | phosphoglycerides |
| Quality Level | 200  |
| SMILES string | [P](=O)([O-])(OC[C@H](OC( |
| storage temp. | −20°C |
| type | Type XI-E |
| Application: | <ul><BR/><li><strong>Fabrication of Microalgae Oil Vesicles for Drug Delivery Applications:</strong> This study highlights the use of L-a-Phosphatidylcholine in creating microalgae oil vesicles, showing promise for encapsulating and delivering hydrophobic drugs effectively (<A class="External" onClick="cmCreateManualPageviewTag('doi.org - P2772 SIGMA', 'EXTERNAL LINKS', 'https://doi.org/10.5650/jos.ess23213', window.location);" rel="nofollow" href="https://doi.org/10.5650/jos.ess23213">Lin YC et al., 2024</A><img src="/images/pixel.png">).</li><BR/><li><strong>Terpenes-Modi<WBR>fied Lipid Nanosystems for Temozolomide, Improving Cytotoxicity against Glioblastoma Human Cancer Cells In Vitro:</strong> L-a-Phosphatidylcholine is employed to formulate terpene-modified lipid nanosystems, enhancing the solubility and bioactivity of temozolomide for glioblastoma treatment (<A class="External" onClick="cmCreateManualPageviewTag('doi.org - P2772 SIGMA', 'EXTERNAL LINKS', 'https://doi.org/10.3390/nano14010055', window.location);" rel="nofollow" href="https://doi.org/10.3390/nano14010055">Pashirova TN et al., 2023</A><img src="/images/pixel.png">).</li><BR/><li><strong>Mitochondria-<WBR>Targeted Lipid Nanoparticles Loaded with Rotenone as a New Approach for the Treatment of Oncological Diseases:</strong> Utilizing L-a-Phosphatidylcholine, this research developed mitochondria-targeted lipid nanoparticles, potentially offering a novel strategy for cancer therapy (<A class="External" onClick="cmCreateManualPageviewTag('doi.org - P2772 SIGMA', 'EXTERNAL LINKS', 'https://doi.org/10.3390/molecules28207229', window.location);" rel="nofollow" href="https://doi.org/10.3390/molecules28207229">Vasileva L et al., 2023</A><img src="/images/pixel.png">).</li><BR/></ul><BR/> |
| Biochem/physiol Actions: | A major structural phospholipid in brain, comprising approx. 15% of total lipid; primarily localized to gray matter. |
| Preparation Note: | P2772 is supplied as a solution in chloroform. The same product is available as a lyophilized powder as Product No. P3556. |
| Symbol |   GHS06,GHS08 |
| Signal word | Danger |
| Hazard statements | H302 - H315 - H319 - H331 - H336 - H351 - H361d - H372 |
| Precautionary statements | P202 - P301 + P312 - P302 + P352 - P304 + P340 + P311 - P305 + P351 + P338 - P308 + P313 |
| Hazard Codes | Xn |
| Risk Statements | 63-20/22-36/38-40-48/20/22 |
| Safety Statements | 26-36/37 |
| RIDADR | UN 1888 6.1 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥99% |
| Storage Temp. | −20°C |
| UNSPSC | 51321705 |