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Paxilline

SIGMA/P2928 - powder, ≥98% (HPLC)

CAS Number: 57186-25-1
Empirical Formula (Hill Notation): C27H33NO4
Molecular Weight: 435.56
MDL Number: MFCD00083464
Linear Formula: C27H33NO4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-P2928-5MG 5 mg
 $480.00
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45-P2928-10MG 10 mg
 $839.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: P2928-10MG

 

assay ≥98% (HPLC)
color faintly yellow
form powder
InChI 1S/C27H33NO4/c1-24(2,30)23-20(29)14-18-21(32-23)10-11-25(3)26(4)15(9-12-27(18,25)31)13-17-16-7-5-6-8-19(16)28-22(17)26/h5-8,14-15,21,23,28,30-31H,9-13H2,1-4H3/t15-,21-,23-,25+,26+,27+/m0/s1
InChI key ACNHBCIZLNNLRS-UBGQALKQSA-N
Quality Level 200 
SMILES string CC(C)(O)C1OC2CCC3(C)C(O)(CCC4Cc5c([nH]c6ccccc56)C34C)C2=CC1=O
storage temp. 2-8°C
Application: Paxilline has been used to block large conductance calcium activated potassium channels (BKCa) in murine smooth muscle cells and in myometrial cells of uterine samples. Paxilline acts as an agonist and activates liver X receptor in atlantic salmon.
Biochem/physiol Actions: Paxilline is a selective blocker of high-conductance Ca2+-activated (Maxi-K) potassium channels. It also blocks big potassium (BK) channels.
Features and Benefits: This compound is featured on the Potassium Channels  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
General description: Paxilline is an indole diterpene metabolite produced by fungi. It has a functionalized pentacyclic core and is a template for the synthesis of a wide variety of derivatives.
Other Notes: Major toxin in Penicillium paxilli
Packaging: 5, 10 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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