Penitrem A

SIGMA/P3053 - ≥95% (HPLC and TLC)

Synonym: Tremortin A

CAS Number: 12627-35-9
Empirical Formula (Hill Notation): C₃₇H₄₄ClNO₆
Molecular Weight: 634.20
MDL Number: MFCD00083465
Linear Formula: C₃₇H₄₄ClNO₆
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-P3053-1MG	1 mg	$375.00 1/EA		Add To Favorites
45-P3053-5MG	5 mg	$1350.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥95% (HPLC and TLC)
form	powder
InChI	1S/C37H44ClNO6/c1-15(2)28-27(40)31-37(45-31)23(43-28)9-10-33(6)34(7)18(8-11-35(33,37)41)29-25-24-21(39-30(25)34)14-20(38)17-12-16(3)19-13-22(32(4,5)44-29)36(19,42)26(17)24/h14,18-19,22-23,27-29,31,39-42H,1,3,8-13H2,2,4-7H3/t18-,19+,22+,23-,27-,28+,29-,31+,33+,34+,35-,36+,37-/m0/s1
InChI key	JDUWHZOLEDOQSR-JKPSMKLGSA-N
Quality Level	200
SMILES string	[H][C@]12CC[C@@]3(C)[C@@](O)(CC[C@@]4([H])[C@]5([H])OC(C)(C)[C@@]6([H])C[C@]7([H])C(=C)Cc8c(Cl)cc9[nH]c(c5c9c8[C@]67O)[C@]34C)[C@]1%10O[C@]%10([H])[C@@H](O)[C@H](O2)C(C)=C
storage temp.	2-8°C

Application:	Penitrem A has been used as Ca²⁺-Activated K⁺ (BK) channel blocker to study its effect on BK current in bag cell neurons.
Biochem/physiol Actions:	Penitrem A intoxication causes ataxia, polypnea, and sustained tremors and may lead to seizures and death. Penitrem A affects the central and peripheral nervous system. It impairs the GABAergic neurotransmission in the cerebellum.
Features and Benefits:	This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Other Notes:	Originally isolated from Penicillium palitans
Packaging:	1, 5 mg in glass bottle

Symbol	GHS06
Signal word	Danger
Hazard statements	H300
Precautionary statements	P301 + P330 + P331 + P310
Hazard Codes	T+
Risk Statements	26/27/28
Safety Statements	36/37/39-45
RIDADR	UN 2811 6.1 / PGII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥95% (HPLC and TLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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