Phosphodiesterase I from Crotalus adamanteus venom
SIGMA/P3134 - Type VI, crude dried venom
Synonym: 5′-Exonuclease; Oligonucleate 5′-nucleotidohydrolase
CAS Number: 9025-82-5
EC Number: 232-806-5
MDL Number: MFCD00131883
Product Type: Chemical
Catalyzes the exonucleolytic cleavage in the 3′- to 5′-direction to yield nucleoside 5′-phosphates.
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: P3134-100MG
| form | crude dried venom |
| Quality Level | 200  |
| storage temp. | −20°C |
| type | Type VI |
| Application: | Phosphodiesterase I from Crotalus adamanteus venom has been used: • for cleaving the 3′-5′ internucleotide bonds in the linear chains of the RNA oligomers • as a model for the hydrolysis of prodrugs in phosphodiesterase assay • as a component in the nucleotide cleavage buffer |
| Biochem/physiol Actions: | Phosphodiesterase I breaks phosphodiester bonds and catalyzes the hydrolysis of various nucleotide polyphosphates. Phosphodiesterase I is released from eucaryotic plasma membranes by phosphatidylinositol-spec |
| General description: | Research area: Cell signaling. PhosphodiesteraseI (PDEI) exists in three isoforms PDE1A, PDE1B, and PDE1C(2) are localized to the central nervous system, cardiovascular, and other organs. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| Enzyme Commission (EC) Number | 3.1.4.1 ( BRENDA  | IUBMB ) |
| UNSPSC | 12352204 |