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Pipamperone dihydrochloride

SIGMA/P3246 - ~99% (HPLC), powder

Synonym: 1′-[4-(4-Fluorophenyl)-4-oxobutyl]-[1,4′-bipiperidine]-4′-carboxamide dihydrochloride; R4050

CAS Number: 2448-68-2
Empirical Formula (Hill Notation): C21H30N3O2F · 2HCl
Molecular Weight: 448.40
EC Number: 219-507-5
MDL Number: MFCD00242980
Linear Formula: C21H30N3O2F · 2HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-P3246-100MG 100 mg
 $286.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: P3246-100MG

 

assay ~99% (HPLC)
color white
form powder
InChI 1S/C21H30FN3O2.2ClH/c22-18-8-6-17(7-9-18)19(26)5-4-12-24-15-10-21(11-16-24,20(23)27)25-13-2-1-3-14-25;;/h6-9H,1-5,10-16H2,(H2,23,27);2*1H
InChI key BMXXSXQVMCXGJM-UHFFFAOYSA-N
originator Johnson & Johnson
Quality Level 100 
SMILES string Cl[H].Cl[H].NC(=O)C1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)N3CCCCC3
solubility H2O: >2.0 mg/mL
Application: Pipamperone dihydrochloride may be used:
• as an internal standard in liquid chromatography with coulometric detection
• as an antipsychotic drugs to test its interaction with human ether-a-go-go-related gene (hERG) channel
• as an internal standard to spike human colostrum samples for reversed phase liquid chromatography- ultraviolet (LC-UV) analysis
Biochem/physiol Actions: D2 dopamine receptor antagonist; 5-HT2 serotonin receptor antagonist; antipsychotic.
Biochem/physiol Actions: Pipamperone, a butyrophenone derivative is a pharmacological chaperone and is a membrane-permeable dopamine receptor D4 (DRD4) antagonist. The affinity of pipamperone is higher for DRD4 and 5-hydroxytryptamine 2A receptor (5-HT2A) in comparison with DRD2. It may be useful therapeutic in treating behavioral disorders and psychomotor agitation symptoms.
Features and Benefits: This compound was developed by Johnson & Johnson . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 100 mg in poly bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Hazard Codes Xn
Risk Statements 22
RIDADR NONH for all modes of transport
WGK Germany WGK 1
Purity ~99% (HPLC)
UNSPSC 12352200

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