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3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester

SIGMA/P3415 - ≥95%, powder

Synonym: N-Succinimidyl 3-(2-pyridyldithio)propionate; SPDP

CAS Number: 68181-17-9
Empirical Formula (Hill Notation): C12H12N2O4S2
Molecular Weight: 312.36
EC Number: 269-034-3
MDL Number: MFCD00009636
Linear Formula: C12H12N2O4S2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-P3415-5MG 5 mg
 $73.70
1/EA		 Add To Favorites
45-P3415-25MG 25 mg
 $225.00
1/EA		 Add To Favorites
45-P3415-100MG 100 mg
 $678.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.

This image depicts SKU: P3415-100MG

 

assay ≥95%
form powder
functional group NHS ester
InChI 1S/C12H12N2O4S2/c15-10-4-5-11(16)14(10)18-12(17)6-8-19-20-9-3-1-2-7-13-9/h1-3,7H,4-6,8H2
InChI key JWDFQMWEFLOOED-UHFFFAOYSA-N
mp 84-86 °C (lit.)
Quality Level 200 
reaction suitability reagent type: cross-linking reagent
SMILES string O=C(CCSSC1=NC=CC=C1)ON2C(CCC2=O)=O
solubility acetone: 50 mg/mL
  DMF: soluble
storage temp. −20°C
Application: 3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester (SPDP) is useful for the preparation of enzyme immunoconjugates and hapten carrier molecule conjugates.
It has been used for antibody conjugation and as a protein cross-linker.
General description: 3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester (SPDP) is a heterobifunctional cross-linking reagent with amine and sulfhydryl reactivity. It is typically coupled initially to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5). Second coupling specific for molecules containing free sulfhydryl by thiol-disulfide exchange buffered at pH 8.0 (7.5-8.5). Alternately, this reagent may be used as a protected thiolating reagent following initial coupling and reduction of linker. It incorporates four atom linker.
Packaging: 25, 100 mg in poly bottle
Packaging: 5 mg in glass bottle
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95%
mp 84-86 °C (lit.)
Storage Temp. −20°C
UNSPSC 12352106

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