Phloridzin dihydrate

SIGMA/P3449 - from apple wood, ≥99% (HPLC)

Synonym: 1-[2-(β-D-Glucopyranosyloxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone; Phloretin 2′-β-D-glucopyranoside; Phloretin 2′-β-D-glucoside; Phlorizin dihydrate

CAS Number: 7061-54-3
Empirical Formula (Hill Notation): C₂₁H₂₄O₁₀ · 2H₂O
Molecular Weight: 472.44
EC Number: 200-487-1
MDL Number: MFCD00149438
Linear Formula: C₂₁H₂₄O₁₀ · 2H₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-P3449-100MG	100 mg	$64.10 1/EA	Add To Favorites
45-P3449-500MG	500 mg	$83.90 1/EA	Add To Favorites
45-P3449-1G	1 g	$156.00 1/EA	Add To Favorites
45-P3449-5G	5 g	$427.00 1/EA	Add To Favorites
45-P3449-10G	10 g	$731.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: P3449-100MG

Properties
Descriptions
Safety Info.
Basic Data

assay	≥99% (HPLC)
biological source	apple wood
form	powder
InChI	1S/C21H24O10.2H2O/c22-9-16-18(27)19(28)20(29)21(31-16)30-15-8-12(24)7-14(26)17(15)13(25)6-3-10-1-4-11(23)5-2-10;;/h1-2,4-5,7-8,16,18-24,26-29H,3,6,9H2;2*1H2/t16-,18-,19+,20-,21-;;/m1../s1
InChI key	XQWBNXSENPTIDY-YXMARJSJSA-N
mp	113-114 °C (lit.)
Quality Level	200
SMILES string	O.O.OC[C@H]1O[C@@H](Oc2cc(O)cc(O)c2C(=O)CCc3ccc(O)cc3)[C@H](O)[C@@H](O)[C@@H]1O

Application:	Phloridzin dihydrate has been used as: • a Na^+-glucose cotransport inhibitor to test its effect in lowering blood glucose • a hexose carrier inhibitor to prevent glucose derivative 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose (2-NBDG) uptake in sycamore cells • a non-specific sodium-glucose co-transporter 2 (SGLT2) inhibitor in embryonic cardiomyocyte cell line H9C2 to investigate its protective effect on Dox-induced cytotoxicity
Biochem/physiol Actions:	Phloridzin is a glycoside present in the leaves and bark of apple. It is also present in peel and pulp of the apple fruit. Phloridzin belongs to the dihydrochalcones class of compounds. Lactase catabolizes phloridzin to phloretin and glucose in small intestine epithelial cells. Phloridzin is an antidiabetic agent and is equally bioavailable as phloretin.
Features and Benefits:	Used to induce experimental glycosuria.
Other Notes:	Dihydrochalcone glycoside found in apple tree
Packaging:	1, 5, 10 g in poly bottle
Packaging:	100, 500 mg in poly bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H315 - H319 - H335
Precautionary statements	P302 + P352 - P305 + P351 + P338
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥99% (HPLC)
mp	113-114 °C (lit.)
UNSPSC	12352200

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