Monoclonal Anti-Placenta Growth Factor-2 antibody produced in rat
SIGMA/P3493 - clone 62526, purified immunoglobulin, lyophilized powder
Synonym: Anti-PlGF-2
MDL Number: MFCD02097209
Product Type: Chemical
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| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | rat |
| clone | 62526, monoclonal |
| conjugate | unconjugated |
| form | lyophilized powder |
| isotype | IgG2a |
| Quality Level | 100  |
| species reactivity | mouse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | indirect ELISA: 0.5-1.0 μg/mL |
| neutralization: suitable | |
| western blot: 1-2 μg/mL | |
| UniProt accession no. | P49764  |
| Biochem/physiol Actions: | Placental growth factors (PlGF) are involved in the growth, migration and survival of endothelial cells. All the four isoforms identified are expressed in placenta and umbilical vein endothelial cells. PlGF bind to specific Flt-1 receptors that result in activation and recruitment of dendritic cells, smooth muscle cells and inflammatory cells. PlGF2 has the ability to bind heparin while PlGF1 is a soluble isoform. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | The antibody neutralizes receptor-ligand interaction. The antibody shows no cross-reactivity with recombinant human PlGF and recombinant human VEGF. |
| Immunogen: | purified recombinant mouse placenta growth factor 2 expressed in insect Sf 21 cells. |
| Physical form: | Lyophilized from a 0.2 μm filtered solution of phosphate buffered saline with 5% trehalose. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 51111800 |