Phe-Arg β-naphthylamide dihydrochloride

SIGMA/P4157 - cathepsin substrate

Synonym: PAβN

CAS Number: 100929-99-5
Empirical Formula (Hill Notation): C₂₅H₃₀N₆O₂ · 2HCl
Molecular Weight: 519.47
MDL Number: MFCD00058046
Linear Formula: C₂₅H₃₀N₆O₂ · 2HCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-P4157-25MG	25 mg	$230.00 1/EA		Add To Favorites
45-P4157-250MG	250 mg	$1140.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (TLC)
form	powder
InChI	1S/C25H30N6O2.ClH/c26-21(15-17-7-2-1-3-8-17)23(32)31-22(11-6-14-29-25(27)28)24(33)30-20-13-12-18-9-4-5-10-19(18)16-20;/h1-5,7-10,12-13,16,21-22H,6,11,14-15,26H2,(H,30,33)(H,31,32)(H4,27,28,29);1H
InChI key	ZMTAZQYLEGNUTJ-UHFFFAOYSA-N
Quality Level	200
SMILES string	Cl.NC(Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(=O)Nc2ccc3ccccc3c2
solubility	water: 50 mg/mL, clear, colorless to faintly yellow
storage temp.	−20°C

Application:	Phe-Arg -naphthylamide dihydrochloride has been used to evaluate the contribution of efflux pumps to antimicrobial resistance. It has also been used for minimal inhibitory concentration testing in the presence of an efflux pump inhibitor.
General description:	Phe-Arg β-naphthylamide, a peptidomimetic compound, is an efflux pump inhibitor (EPI). It acts on the major multidrug resistance efflux transporters of Gram-negative bacteria. Phe-Arg -naphthylamide lowers fluoroquinolone resistance in Pseudomonas aeruginosa.
General description:	Substrate for dipeptidyl aminopeptidase I (cathepsin C).
Packaging:	Bottomless glass bottle. Contents are inside inserted fused cone.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (TLC)
Storage Temp.	−20°C
UNSPSC	12352204

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