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PJ-34 hydrochloride hydrate

SIGMA/P4365 - ≥98% (HPLC), powder

Synonym: PARP Inhibitor VIII; PJ 34 HCl; N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-(N,N-dimethylamino)acetamide hydrochloride

CAS Number: 344458-15-7
Empirical Formula (Hill Notation): C17H17N3O2 · HCl · xH2O
Molecular Weight: 331.80 (anhydrous basis)
Linear Formula: C17H17N3O2 · HCl · xH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-P4365-5MG 5 mg
 $319.00
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assay ≥98% (HPLC)
color white to yellow
form powder
InChI 1S/C17H17N3O2.ClH.H2O/c1-20(2)10-16(21)18-11-7-8-15-14(9-11)12-5-3-4-6-13(12)17(22)19-15;;/h3-9H,10H2,1-2H3,(H,18,21)(H,19,22);1H;1H2
InChI key YCALIZUKAFUQCH-UHFFFAOYSA-N
Quality Level 100 
SMILES string Cl[H].[H]O[H].CN(C)CC(=O)Nc1ccc2NC(=O)c3ccccc3-c2c1
solubility H2O: 22 mg/mL
storage condition desiccated
Application: PJ-34 hydrochloride hydrate has been used:
• as a poly(ADP-ribose) polymerase (PARP) inhibitor 1 in rats to test the effect of PAPR1 in neuropathic pain
• as a component of protein extraction buffer to enable visualization of the high-molecular-weight smear of PARylated proteins in various cell samples
• as PARP inhibitor in murine MLE-12 epithelial cell line
Biochem/physiol Actions: PJ-34 is a potent poly(ADP-ribose) polymerase (PARP) inhibitor.
Biochem/physiol Actions: PJ-34 is a prototypic poly(ADP-ribose) polymerase 1 (PARP-1) inhibitor.
Packaging: 5 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
UNSPSC 12352200

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