cis-Diammineplatinum(II) dichloride
SIGMA/P4394 - crystalline
Synonym: cis-Dichlorodiammine platinum(II); cis-Platinum(II) diammine dichloride; Cisplatin
CAS Number: 15663-27-1
Empirical Formula (Hill Notation): H6Cl2N2Pt
Molecular Weight: 300.05
EC Number: 239-733-8
MDL Number: MFCD00011623
Linear Formula: Pt(NH3)2Cl2
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: P4394-100MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: P4394-1G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: P4394-250MG
| antibiotic activity spectrum | neoplastics |
| color | yellow |
| form | crystalline |
| InChI | 1S/2ClH.2H3N.Pt/h2*1H;2*1 |
| InChI key | LXZZYRPGZAFOLE-UHFFFAOYSA |
| mode of action | DNA synthesis | interferes |
| mp | 270 °C (lit.) |
| originator | Corden |
| Quality Level | 200  |
| SMILES string | N.N.Cl[Pt]Cl |
| Application: | cis-Diammineplatinum(II) dichloride has been used: • in cell viability measurement in cochlear explants • in the inhibition of cell proliferation and chemosensitivity in ovarian cancer cell lines • in MTT [3-(4,5-Dimethylthiazol-2 |
| Biochem/physiol Actions: | Potent chemoimmunotherapeutic drug; stimulates the immune responses by activating macrophages and other cells of the immune system. Cisplatin-treated macrophages show increased antigen presentation function in vitro. Treatment increased cellular NF-κB content and translocation in macrophages. Cisplatin effects are regulated by kinases, phosphatases, and Ca2+/calmodulin. Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand crosslinks. |
| Biochem/physiol Actions: | Potent platinum-based antineoplastic agent. Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand cross-links. |
| Features and Benefits: | This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Features and Benefits: | This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Features and Benefits: | This compound was developed by Corden . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here . |
| Packaging: | 1 g in glass bottle |
| Packaging: | 100, 250 mg in glass bottle |
| Packaging: | 25 mg in glass insert |
| Preparation Note: | This product is to be stored in room temperature. Keep the product tightly closed in a well-ventilated place. Dry. Please view the Safety Data Sheet for more information. |
| Symbol |   GHS06,GHS08 |
| Signal word | Danger |
| Hazard statements | H300 - H315 - H317 - H319 - H334 - H335 - H350 |
| Precautionary statements | P201 - P280 - P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338 |
| Hazard Codes | T |
| Risk Statements | 45-25-41 |
| Safety Statements | 53-26-39-45 |
| RIDADR | UN 3288 6.1 / PGII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| mp | 270 °C (lit.) |
| UNSPSC | 12352200 |