Polyguanylic acid potassium salt
SIGMA/P4404 - lyophilized powder
Synonym: Poly(G) potassium salt
CAS Number: 54684-83-2
MDL Number: MFCD00131976
Product Type: Chemical
Polyguanylic acid potassium salt unit structure
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: P4404-25MG
| assay | ≥95% (TLC) |
| biological source | enzyme from (synthesis) |
| form | lyophilized powder |
| quality | ≤5% free nucleotides |
| Quality Level | 200  |
| solubility | water: 19.60-20.40 mg/mL, clear to slightly hazy, colorless to light yellow |
| storage temp. | −20°C |
| Application: | Polyguanylic acid (PolyG) is used to study the effects of ionizing radiation on formation and stability of G-quadruplex structures and as a target molecule for physicochemical studies of electronic excitation (vibrational spectra) of guanosine. |
| Application: | Polyguanylic acid potassium salt has been used: • as a ligand for surface neuropilin-1 (NRP1) for internalization studies • for intercalation studies with trisubstituted and disubstituted triazole-linked phenyl derivatives CL41, CL42 and CL2r50 using voltammetry method • as a synthetic polynucleotide for agarose gel electrophoresis analysis |
| Biochem/physiol Actions: | Polyguanylic acid acts as a ligand for scavenger receptor and reduces the surface expression neuropilin-1 in endothelial cells. |
| General description: | Polyguanylic acid takes up a four-stranded helical structure. It is synthetically produced in Thermus thermophilus from guanosine diphosphate (GDP) and its synthesis is catalyzed by the enzyme polynucleotide phosphorylase. |
| Packaging: | 25 mg in poly bottle |
| Packaging: | 5 mg in glass bottle |
| Preparation Note: | Prepared from GDP using polynucleotide phosphorylase |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (TLC) |
| Storage Temp. | −20°C |
| UNSPSC | 41106305 |