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Phosphodiesterase I from Crotalus atrox (Western Diamondback Rattlesnake)

SIGMA/P4506 - Type IV, crude dried venom

Synonym: 5′-Exonuclease; Oligonucleate 5′-nucleotidohydrolase

EC Number: 232-870-4
MDL Number: MFCD00131883
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-P4506-100MG 100 mg
 $100.00
1/EA		 Add To Favorites
45-P4506-500MG 500 mg
 $352.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: P4506-100MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: P4506-500MG

 

form crude dried venom
Quality Level 200 
storage temp. −20°C
type Type IV
Application: Phosphodiesterase I from Crotalus atrox (Western Diamondback Rattlesnake) has been used to analyse its effect on intracellular calcium concentration of neutrophils. It has also been used in combination with other enzymes to determine the activity of phosphatase enzyme.
Application: Phosphodiesterase I, product P4506 from western diamondback rattlesnake, is used in phosphodiesterase activation assays for calmodulin. It is added to hydrolyze AMP.
Biochem/physiol Actions: Phosphodiesterase I breaks phosphodiester bonds and catalyzes the hydrolysis of various nucleotide polyphosphates. Phosphodiesterase I is released from eucaryotic plasma membranes by phosphatidylinositol-specific phospholipase C. Phosphodiesterase I (PDEI) can hydrolyze 3′,5′-cyclicadenosine monophosphate (cAMP) and 3′,5′-cyclic guanosine monophosphate (cGMP).It forms a complex with Ca2+/calmodulin (CaM) that leads to the activationof its catalytic activity.PDEIshows biotherapeutic effects for the treatment of cancer, diseases, neurocognitive,pulmonary, metabolic, heart, renal, neurological disorders, and endocrineabnormalities.
General description: Research area: Cell signalingPhosphodiesteraseI (PDEI) exists in three isoforms PDE1A,PDE1B, and PDE1C(2) that are locatedin cardiovascular, central nervous system, and other organs.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Storage Temp. −20°C
Enzyme Commission (EC) Number 3.1.4.1   ( BRENDA  | IUBMB  )
UNSPSC 12352204

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