Valproic acid sodium salt
SIGMA/P4543 - 98%
Synonym: 2-propylpentanoic acid sodium; Sodium 2-propylpentanoate; Sodium valproate
CAS Number: 1069-66-5
Empirical Formula (Hill Notation): C8H15NaO2
Molecular Weight: 166.19
EC Number: 213-961-8
MDL Number: MFCD00078604
Linear Formula: C8H15NaO2
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: P4543-100G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: P4543-25G
| assay | 98% |
| form | powder |
| InChI | 1S/C8H16O2.Na/c1-3-5-7(6- |
| InChI key | AEQFSUDEHCCHBT-UHFFFAOYSA |
| originator | Abbott |
| Quality Level | 200  |
| SMILES string | [Na+].CCCC(CCC)C([O-])=O |
| solubility | H2O: 50 mg/mL |
| Application: | Valproic acid sodium salt has been used: • in resazurin viability assay • to systematically study its effects of clinical doses on brain volume and offspring behavior • to study its effect on atherosclerotic lesion size • in genetic expression studies in mice |
| Biochem/physiol Actions: | Anti-convulsant that also has efficacy as a mood stabilizer in bipolar disorder. |
| Features and Benefits: | This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Features and Benefits: | This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Features and Benefits: | This compound was developed by Abbott . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here . |
| General description: | The antiepileptic effects of Valproic acid (VPA) are achieved by reducing high-frequency neuronal firing through the blockage of voltage-gated sodium, potassium, and calcium channels. This medication affects the biochemical occurrence of aura and impacts pain perception by modulating GABA or glutamate-mediated neurotransmission. Additionally, VPA influences signaling systems such as the Wnt/beta-catenin and ERK pathways, interfering with inositol and arachidonate metabolism. Furthermore, VPA is crucial in expressing multiple genes involved in cell survival, transcription regulation, ion homeostasis, signaltransduction, and cytoskeletal modifications. Both immediate biochemical effects and long-term genomic influences explain the underlying effect of VPA in treating various conditions. Valproic acid is an anticonvulsant and mood-stabilizing drug. It is used to treat epilepsy and bipolar disorder. Valproic acid helps to repress the Warburg effect and the development of tumor in neuroblastoma. |
| Packaging: | 10, 25, 100 g in glass bottle |
| Symbol |   GHS07,GHS08 |
| Signal word | Warning |
| Hazard statements | H302 - H361d |
| Precautionary statements | P201 - P202 - P264 - P270 - P301 + P312 - P308 + P313 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Safety Statements | 36/37 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Purity | 98% |
| UNSPSC | 12352106 |