Anti-Purinergic Receptor P2Y12 antibody produced in rabbit
SIGMA/P4871 - affinity isolated antibody, lyophilized powder
Synonym: Anti-ADPG-R; Anti-BDPLT8; Anti-HORK3; Anti-P2T(AC); Anti-P2Y(12)R; Anti-P2Y(AC); Anti-P2Y(ADP); Anti-P2Y(cyc); Anti-P2Y12
MDL Number: MFCD04975335
Product Type: Chemical
Immunohistochemistry Anti-P2Y12 Receptor: Cat. No. P4871: Immunohistochemical staining of Mouse brain sections using Anti-P2Y12 Receptor antibody, (red). The region shown in this picture is the entorhinal cortex in Mouse brain. The P2Y12 positive fibers (arrows) run from the corpus callosum (triangles) into the deep layers of the entorhinal cortex. Sytox green is used as the counterstain.
Immunoblotting Anti-P2Y12 Receptor: Cat. No. P4871: Western blot analysis of Rat brain membranes (lanes 1,2) and human platelets (lanes 3,4). Lanes 1,3. Anti-P2Y12 Receptor antibody (1:200). 2,4. Anti-P2Y12 Receptor antibody, preincubated with the control peptide antigen.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | lyophilized powder |
| Quality Level | 200  |
| species reactivity | human, mouse, rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: suitable using mouse brain sections |
| western blot: 1:200 using rat brain membranes or human platelets | |
| UniProt accession no. | Q9H244  |
| Application: | Anti-Purinergic Receptor P2Y12 antibody produced in rabbit has been used in Western blotting. |
| Biochem/physiol Actions: | Purinergic receptor or platelet adenosine 5′-diphosphate (ADP) receptor P2Y12 has a role in platelet aggregation induced by ADP. Dysfunctional mutations in the protein have been linked with bleeding disorders. Studies have indicated that mice deficient in the P2Y12 receptor show decreased tumor metastasis. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Purinergic receptor or platelet adenosine 5′-diphosphate (ADP) receptor P2Y12 is a G-protein-coupled receptor. The gene encoding it is localized on human chromosome 3q25.1. |
| Immunogen: | peptide corresponding to amino acid residues 125-142 of human P2Y12. This epitope is highly homologous in rat and mouse (16/18 residues identical). |
| Physical form: | Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide. |
| Hazard statements | H412 |
| Precautionary statements | P273 |
| Hazard Codes | Xn |
| Risk Statements | 21/22-52/53 |
| Safety Statements | 36/37-61 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |