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β-Acetyl-γ-O-hexadecyl-L-α-phosphatidylcholine hydrate

SIGMA/P4904 - ≥98%

Synonym: 1-Hexadecyl-2-acetyl-sn-glycero-3-phosphocholine; 1-O-Palmityl-2-acetyl-sn-glycero-3-phosphocholine monohydrate; 2-Acetyl-1-hexadecyl-sn-glycero-3-phosphocholine; 3-sn-Phosphatidylcholine, 1-hexadecyl-2-acetyl; PAF(C16); Platelet activating factor

CAS Number: 74389-68-7 (anhydrous)
Empirical Formula (Hill Notation): C26H54NO7P · xH2O
Molecular Weight: 523.68 (anhydrous basis)
MDL Number: MFCD00150679
Linear Formula: C26H54NO7P · xH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-P4904-1MG 1 mg
 $64.10
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45-P4904-5MG 5 mg
 $159.00
1/EA		 Add To Favorites
45-P4904-10MG 10 mg
 $377.00
1/EA		 Add To Favorites
45-P4904-25MG 25 mg
 $531.00
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assay ≥98%
form powder
InChI 1S/C26H54NO7P.H2O/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21-31-23-26(34-25(2)28)24-33-35(29,30)32-22-20-27(3,4)5;/h26H,6-24H2,1-5H3;1H2/t26-;/m1./s1
InChI key HFMSDOHEENWULV-UFTMZEDQSA-N
Quality Level 200 
SMILES string O.CCCCCCCCCCCCCCCCOC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(C)=O
storage temp. −20°C
Application: β-Acetyl-γ-O-hexadecyl-L-α-phosphatidylcholine has been used:• to study its effects on phagocytic activity and production of superoxide anion in equine alveolar macrophage and blood neutrophils
• to study its protective effects against cisplatin-induced cell death in a human melanoma cell line in vitro
• to determine its effects on cervical ripening and leukocyte infiltration in rat models
Biochem/physiol Actions: β-Acetyl-γ-O-hexadecyl-L-α-phosphatidylcholine or platelet-activating factor (PAF), is a phospholipid, and a pro-inflammatory lipid mediator. It acts as a ligand for G protein-coupled platelet-activating factor (PAF) receptors and participates in several biological processes such as airway constriction, hypotension, platelet activation, and increased vascular permeability. PAF is released by various cells such as platelets, neutrophils, endothelial cells, and monocytes/macrophages. The levels of PAF are low in the blood due to its rapid metabolism by PAF acetylhydrolase and low production.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98%
Storage Temp. −20°C
UNSPSC 12352211

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