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Poly(deoxyinosinic-deoxycytidylic) acid sodium salt

SIGMA/P4929 - double-stranded alternating copolymer

Synonym: Poly(dI-dC) • Poly(dI-dC) sodium salt

CAS Number: 118578-37-3
MDL Number: MFCD00131970
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-P4929-5UN 5 units
 $199.00
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45-P4929-10UN 10 units
 $315.00
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45-P4929-25UN 25 units
 $627.00
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biological source synthetic (organic)
form powder
Quality Level 200 
storage temp. −20°C
Application: Poly(deoxyinosinic-deoxycytidylic) acid (Poly(dI-dC) • Poly(dI-dC)) is an alternating copolymer used as a DNA substrate for evaluation of DNA methytransfeases, such as DNA-methyltransferase 1 and as double-stranded DNA model for conformational studies of DNA structure dynamics and drug, small molecule, interactions.
Application: Poly(deoxyinosinic-deoxycytidylic) acid sodium salt has been used in a study that synthesized and characterized bis(2-(pyrimidin-2-γl)ethoxy)alkanes and their pharmacological activity. Poly(deoxyinosinic-deoxycytidylic) acid sodium salt has also been used in a study that investigated the growth of calcium carbonate films on LB/LbL matrices.
Application: Poly(deoxyinosinic-deoxycytidylic) acid sodium salt has been used in the electrophoretic mobility shift assay in p65 protein and neuro-2A protein lysate. It has also been used as a substrate in the protein arginine methyltransferase 1 (PRMT1) and DNA methyltransferase 1 (DNMT1) selectivity assay.
Biochem/physiol Actions: Poly(2′-deoxyinosinic-2′-deoxycytidylic acid), poly(dI-dC) is a synthetic DNA substrate. At high salt, Poly(dI-dC) exists in left handed helical conformation and reverts to right-handed form upon decreasing salt. It is used in electrophoretic mobility shift assay (EMSA).
Other Notes: Double-stranded alternating copolymer
Other Notes: One unit will yield an A260 of 1.0 in 1.0 ml of 20 mM sodium phosphate/100 mM NaCl, pH 7.0 (1 cm light path)
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Storage Temp. −20°C
UNSPSC 41106305

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