5α-Pregnan-3α-ol-11,20-dione

SIGMA/P5052 - powder, ≥98% (TLC)

Synonym: 3-Hydroxy-5α-pregnane-11,20-dione; Alfaxalone

CAS Number: 23930-19-0
MDL Number: MFCD00083468
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-P5052-10MG	10 mg	$243.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (TLC)
color	white
drug control	USDEA Schedule IV
form	powder
InChI	1S/C21H32O3/c1-12(22)16-6-7-17-15-5-4-13-10-14(23)8-9-20(13,2)19(15)18(24)11-21(16,17)3/h13-17,19,23H,4-11H2,1-3H3/t13-,14+,15-,16+,17-,19+,20-,21+/m0/s1
InChI key	DUHUCHOQIDJXAT-OLVMNOGESA-N
Quality Level	200
SMILES string	[H][C@@]12CC[C@@]3([H])[C@]4([H])CC[C@H](C(C)=O)[C@@]4(C)CC(=O)[C@]3([H])[C@@]1(C)CC[C@@H](O)C2
solubility	chloroform: ≥5 mg/mL, clear, colorless

Biochem/physiol Actions:	Neurosteroid; positive allosteric modulator of the GABA_A receptor; anesthetic.
Biochem/physiol Actions:	Synthetic steroid compound alphaxalone (AFX) - 5α-Pregnan-3α-ol-11,20-dione- is a neurosteroid that directly activates and potentiates GABA_A receptor-activated membrane current (IGABA). It acts as a positive allosteric modulator of the GABA_A receptor; anesthetic. The alpha subunit subtype of GABA_A determines the efficacy, but not the potency, of AFX neuroactive steroid to potentiate IGABA.

Symbol	GHS06
Signal word	Danger
Hazard statements	H301
Precautionary statements	P301 + P310
Hazard Codes	Xn
Risk Statements	22
Safety Statements	22-36
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (TLC)
UNSPSC	12352200

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