Paromomycin sulfate salt
SIGMA/P5057 - powder, BioReagent, suitable for cell culture, potency: ≥675 μg per mg
CAS Number: 1263-89-4
Empirical Formula (Hill Notation): C23H45N5O14 · xH2SO4
Molecular Weight: 615.63 (free base basis)
Linear Formula: C23H45N5O14 · xH2SO4
Product Type: Chemical
| antibiotic activity spectrum | Gram-negative bacteria |
| Gram-positive bacteria | |
| form | powder |
| InChI | 1S/C23H45N5O14.CH4/c24-2- |
| InChI key | OYJABWUHUYVDMJ-UDXJMMFXSA |
| mode of action | protein synthesis | interferes |
| potency | ≥675 μg per mg |
| product line | BioReagent |
| Quality Level | 200  |
| SMILES string | O[C@H]1[C@H](O)[C@@H](CO) |
| technique(s) | cell culture | mammalian: suitable |
| Application: | • Paromomycin sulfate salt has been used as a: • reference compound in antileishmanial activity • RNA-binding ligand and interacts with aptamer. This interaction prevents the binding (and cutting) of dicer to RNA duplex. Recommended for use in cell culture applications at 100mg/L. |
| Application: | Paromomycin sulfate salt has been used as a positive control to compare the purine analog antiviral 2′,3′-dideoxyinosine (ddI). |
| Biochem/physiol Actions: | Antimicrobial spectrum: Gram-negative and Gram-positive bacteria, some protozoan species, and limited antihelminth. Mode of Action: Inhibits initiation and elongation during protein synthesis. |
| Biochem/physiol Actions: | Paromomycin inhibits the initiation and elongation steps of protein synthesis by binding to 16S ribosomal RNA. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced and leads to cell death. |
| Biochem/physiol Actions: | Paromomycin possesses antileishmanial and antibacterial activities. It is used to cure visceral leishmaniasis (VL) and cutaneous leishmaniasis (CL). This aminocyclitol glycoside is active against gram-negative and gram-positive bacteria. It is also active against E. histolytica, D. fragilis and several cestodes, like Taenia saginata, Taenia solium etc. |
| General description: | Chemical structure: aminoglycoside |
| General description: | Paromomycin or aminosidine, an aminoglycoside belongs to the class of aminoglycosides. This nonabsorbable antibiotic is found at high level in the lumen of the colon. |
| Other Notes: | 1g,5g |
| Other Notes: | Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| UNSPSC | 12352207 |